{"created":"2024-10-28T05:31:07.594303+00:00","id":2004669,"links":{},"metadata":{"_buckets":{"deposit":"966fbd66-82f1-45bb-b199-9fe4a42edb9f"},"_deposit":{"created_by":7,"id":"2004669","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004669"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004669","sets":["1713829974766:1713854681789:1716364518346:1716421262118","1713853213384:1713853295607"]},"author_link":["1113","1234","1579","1577","1156"],"control_number":"2004669","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"27","bibliographicPageStart":"19","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There is crosstalk in intracellular signaling between Angiotensin II (Ang II) and insulin. We hypothesized that the underlying mechanism might be related to changes in cytoskeleton. In the presence of 100 nM of Ang II, insulin-induced glucose uptake was decreased and insulin-induced actin filament organization was inhibited. PKC inhibitors, including GF 109203x and p38 MAPK inhibitor (SB 203580) neither improved insulin-induced actin reorganization nor glucose uptake. In contrast, the Ang II-induced inhibition of glucose uptake and actin filament disorganization was reversed by 10 μmol ERK 1/2 MAPK inhibitor (PD 98059). Pretreatment of Ang II increased ERK1/2 phosphorylation and inhibited insulin-induced Akt phosphorylation. The effect of Ang II on ERK 1/2 phosphorylation was blocked by Ang II type 1 receptor antagonists, RNH 6270 and PD 98059 but not by SB 203580 or Guanosine-5’-O-(2-ThioDiphosphate), a G-protein inhibitor. We next tested the effect of broad-spectrum matrix metalloproteinase (MMP) inhibitor (GM 6001) on Ang II-inhibition of insulin signaling pathway. GM 6001 did not improve Ang II-induced actin filament disorganization and did not inhibit ERK1/2 phosphorylation. From these data in L6 myotube, we conclude that Ang II negatively regulates the insulin signal not through MMP signaling pathway but specifically through MMP-independent ERK 1/2 activation pathway, providing an alternative molecular mechanism for angiotensin-induced insulin resistance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.54.19"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.54.19","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"148371"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nazari, Hossein","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"髙橋, 章","creatorNameLang":"ja"},{"creatorName":"タカハシ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"髙橋","familyNameLang":"ja"},{"familyName":"タカハシ","familyNameLang":"ja-Kana"},{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"章","givenNameLang":"ja"},{"givenName":"アキラ","givenNameLang":"ja-Kana"},{"givenName":"Akira","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1579","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60133/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60133/profile-ja.html"},{"nameIdentifier":"90304047","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90304047"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原田, 永勝","creatorNameLang":"ja"},{"creatorName":"ハラダ, ナガカツ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Nagakatsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"原田","familyNameLang":"ja"},{"familyName":"ハラダ","familyNameLang":"ja-Kana"},{"familyName":"Harada","familyNameLang":"en"}],"givenNames":[{"givenName":"永勝","givenNameLang":"ja"},{"givenName":"ナガカツ","givenNameLang":"ja-Kana"},{"givenName":"Nagakatsu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1156","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40359914","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40359914"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"馬渡, 一諭","creatorNameLang":"ja"},{"creatorName":"マワタリ, カズアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Mawatari, Kazuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"馬渡","familyNameLang":"ja"},{"familyName":"マワタリ","familyNameLang":"ja-Kana"},{"familyName":"Mawatari","familyNameLang":"en"}],"givenNames":[{"givenName":"一諭","givenNameLang":"ja"},{"givenName":"カズアキ","givenNameLang":"ja-Kana"},{"givenName":"Kazuaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1234","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80408/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/80408/profile-ja.html"},{"nameIdentifier":"40352372","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40352372"}]},{"creatorNames":[{"creatorName":"ナカノ, マサユキ","creatorNameLang":"ja"},{"creatorName":"ナカノ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakano, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岸, 和弘","creatorNameLang":"ja"},{"creatorName":"キシ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishi, Kazuhiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"蛯名, 洋介","creatorNameLang":"ja"},{"creatorName":"エビナ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ebina, Yousuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"蛯名","familyNameLang":"ja"},{"familyName":"エビナ","familyNameLang":"ja-Kana"},{"familyName":"Ebina","familyNameLang":"en"}],"givenNames":[{"givenName":"洋介","givenNameLang":"ja"},{"givenName":"ヨウスケ","givenNameLang":"ja-Kana"},{"givenName":"Yousuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60590/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60590/profile-ja.html"},{"nameIdentifier":"00112227","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00112227"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中屋, 豊","creatorNameLang":"ja"},{"creatorName":"ナカヤ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakaya, Yutaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"中屋","familyNameLang":"ja"},{"familyName":"ナカヤ","familyNameLang":"ja-Kana"},{"familyName":"Nakaya","familyNameLang":"en"}],"givenNames":[{"givenName":"豊","givenNameLang":"ja"},{"givenName":"ユタカ","givenNameLang":"ja-Kana"},{"givenName":"Yutaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1577","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60130/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60130/profile-ja.html"},{"nameIdentifier":"50136222","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50136222"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-28"}],"displaytype":"detail","filename":"jmi_54_1-2_19.pdf","filesize":[{"value":"1010 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004669/files/jmi_54_1-2_19.pdf"},"version_id":"e1fa5b32-c8da-495d-85d3-dce1faf7e73f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"insulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin II","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytoskeleton","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin receptor blockers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metalloproteinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Angiotensin II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Angiotensin II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421262118"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-28"},"publish_date":"2018-05-28","publish_status":"0","recid":"2004669","relation_version_is_last":true,"title":["Angiotensin II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:07:22.710759+00:00"}