{"created":"2024-10-28T05:34:20.058597+00:00","id":2004709,"links":{},"metadata":{"_buckets":{"deposit":"ca2d3523-9ddb-4937-b7cc-eb583af8fd05"},"_deposit":{"created_by":7,"id":"2004709","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004709"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004709","sets":["1713853213384:1713853295607"]},"author_link":["1648"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Parathyroid cells : structure or Ca2+ sensing receptor ","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"810","bibliographicPageStart":"805","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"日本臨牀","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of clinical medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Using expression in Xenopus oocytes, Brown et al. cloned a bovine parathyroid Ca2+ sensing receptor (BoPCaRl). The 1,085 amino acid membrane protein is included in a class of putative seven transmembrane spanning structures that activate the phosphoinositol pathway through G proteins. Receptor activation presumably elevates intracellular Ca2+ to inhibit secretion of PTH. BoPCaRl has a big extracellular domain at the amino terminus. BoPCaRl is most similar to the metabotropic glutamate receptor. BoPCaRl mRNA is found in cells that have well known Ca2+ sensing function. Inheritance of one inactive Ca2+ sensing receptor gene causes familial hypocalciuric hypercalcemia (FHH) and autosomal dominant hypocalcemia. Mutations in the extracellular domain and in a portion of the third intracellular loop domain decrease the receptor’s sensitivity, causing FHH. Extracellular domain mutations increase the receptor’s activity at low Ca2+ concentration to cause autosomal familial hypocalcemia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨牀社","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00471852","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00198641","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"71893"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]},{"creatorNames":[{"creatorName":"斎藤, 史郎","creatorNameLang":"ja"},{"creatorName":"サイトウ, シロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Shiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-22"}],"displaytype":"detail","filename":"jjcm_53_4_805.pdf","filesize":[{"value":"2.51 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004709/files/jjcm_53_4_805.pdf"},"version_id":"03201cdb-6fc0-45c6-b870-4f09d73fa7de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ca2+ sensing receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parathyroid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"G protein coupled receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Familial  hypocalciuric hypercalcemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Autosomal dominant hypocalcemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"副甲状腺細胞 : カルシウム感受性受容体の構造 (特集 : 副甲状腺(上皮小体)疾患)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"副甲状腺細胞 : カルシウム感受性受容体の構造 (特集 : 副甲状腺(上皮小体)疾患)","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-22"},"publish_date":"2018-05-22","publish_status":"0","recid":"2004709","relation_version_is_last":true,"title":["副甲状腺細胞 : カルシウム感受性受容体の構造 (特集 : 副甲状腺(上皮小体)疾患)"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:19.891448+00:00"}