{"created":"2024-10-28T05:36:28.165045+00:00","id":2004738,"links":{},"metadata":{"_buckets":{"deposit":"736d40d5-79ea-4216-96f7-9c056d39f4f9"},"_deposit":{"created_by":7,"id":"2004738","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004738"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004738","sets":["1713853213384:1713853295607"]},"author_link":["1225","170","1574"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"248","bibliographicPageStart":"245","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Serotonin transporters (SERTs) are pre-synaptic proteins specialized for the clearance of serotonin following vesicular release at central nervous system (CNS) and enteric nervous system synapses. SERTs are high affinity targets in vivo for antidepressants such as serotonin selective reuptake inhibitors (SSRIs). These include ‘medical’ psychopharmacological agents such as analgesics and antihistamines, a plant extract called St John’s Wort (Hypericum) . Osteoclasts are the primary cells responsible for bone resorption. They arise by the differentiation of osteoclast precursors of the monocyte/macrophage lineage. The expression of SERTs was increased in RANKL-induced osteoclast-like cells. Using RANKL stimulation of RAW264.7 cells as a model system for osteoclast differentiation, we studied the direct effects of food factor on serotonin uptake. The SSRIs (fluoxetine and fluvoxamine) inhibited markedly (～95%) in serotonin transport in differentiated osteoclast cells. The major components of St. John’s Wort, hyperforin and hypericine were significantly decreased in serotonin transport activity. Thus, a new in vitro model using RANKL-induced osteoclast-like cells may be useful to analyze the regulation of SERT by food factors and SSRIs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.52.245"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.52.245","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"133903"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 美紀子","creatorNameLang":"ja"},{"creatorName":"イトウ, ミキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Mikiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハイトウ, サキコ","creatorNameLang":"ja"},{"creatorName":"ハイトウ, サキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Haito, Sakiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フルモト, マリ","creatorNameLang":"ja"},{"creatorName":"フルモト, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Furumoto, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"河合, 慶親","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺尾, 純二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-06-13"}],"displaytype":"detail","filename":"jmi_52_supple_245.pdf","filesize":[{"value":"557 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004738/files/jmi_52_supple_245.pdf"},"version_id":"fec29561-3e12-48ec-9959-a9291a5f7c33"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"serotonin transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SSRI","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"St John’s wort","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Approach to novel functional foods for stress control : 4. Regulation of serotonin transporter by food factors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Approach to novel functional foods for stress control : 4. Regulation of serotonin transporter by food factors","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-13"},"publish_date":"2018-06-13","publish_status":"0","recid":"2004738","relation_version_is_last":true,"title":["Approach to novel functional foods for stress control : 4. Regulation of serotonin transporter by food factors"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T05:36:35.761551+00:00"}