{"created":"2024-10-28T05:39:30.070715+00:00","id":2004779,"links":{},"metadata":{"_buckets":{"deposit":"b074813f-4f73-49a5-b0bf-c0cad84cedf1"},"_deposit":{"created_by":7,"id":"2004779","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004779"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004779","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1574","1584","329","698"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ナトリウム依存性リン酸トランスポーターとニコチンアミドホスホリボシルトランスフェラーゼは血漿無機リン酸濃度の日内変動に関与する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Liver-kidney axis and plasma Pi rhythm","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1085","bibliographicPageStart":"1073","bibliographicVolumeNumber":"93","bibliographic_titles":[{"bibliographic_title":"Kidney International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Circulating inorganic phosphate exhibits a remarkable daily oscillation based on food intake. In humans and rodents, the daily oscillation in response to food intake may be coordinated to control the intestinal absorption, renal excretion, cellular shifts, and extracellular concentration of inorganic phosphate. However, mechanisms regulating the resulting oscillation are unknown. Here we investigated the roles of the sodium phosphate cotransporter SLC34 (Npt2) family and nicotinamide phosphoribosyltransferase (Nampt) in the daily oscillation of plasma inorganic phosphate levels. First, it is roughly linked to urinary inorganic phosphate excretion. Second, expression of renal Npt2a and Npt2c, and intestinal Npt2b proteins also exhibit a dynamic daily oscillation. Analyses of Npt2a, Npt2b, and Npt2c knockout mice revealed the importance of renal inorganic phosphate reabsorption and cellular inorganic phosphate shifts in the daily oscillation. Third, experiments in which nicotinamide and a specific Nampt inhibitor (FK866) were administered in the active and rest phases revealed that the Nampt/NAD+ system is involved in renal inorganic phosphate excretion. Additionally, for cellular shifts, liver-specific Nampt deletion disturbed the daily oscillation of plasma phosphate during the rest but not the active phase. In systemic Nampt+/- mice, NAD levels were significantly reduced in the liver, kidney, and intestine, and the daily oscillation (active and rest phases) of the plasma phosphate concentration was attenuated. Thus, the Nampt/ NAD+ system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"International Society of Nephrology","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00852538","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15231755","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00710996","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11629608","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3138号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-02-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Atsumi Miyagawaの学位論文として提出され, 学位審査・授与の対象となっている。\n著者の申請により要約(2018-05-17公開)に替えて論文全文を公開(2018-08-06)\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第247号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.kint.2017.11.022"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.kint.2017.11.022","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"342186"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮川, 淳美","creatorNameLang":"ja"},{"creatorName":"ミヤガワ, アツミ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyagawa, 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KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004779/files/k3138_abstract_review.pdf"},"version_id":"0960565c-8ca0-4c9a-8d9e-fd694f65bc11"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-08-06"}],"displaytype":"detail","filename":"k3138_fulltext.pdf","filesize":[{"value":"2.33 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004779/files/k3138_fulltext.pdf"},"version_id":"6eef2f54-b2fe-4963-88e8-185f398ab86a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"daily oscillation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NAD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nampt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Npt2a","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Npt2c","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-17"},"publish_date":"2018-05-17","publish_status":"0","recid":"2004779","relation_version_is_last":true,"title":["The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of the plasma inorganic phosphate concentration"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T09:17:45.920705+00:00"}