{"created":"2024-10-28T05:39:34.119465+00:00","id":2004780,"links":{},"metadata":{"_buckets":{"deposit":"f1dfe12c-0b33-4559-8224-992ba4a1b729"},"_deposit":{"created_by":7,"id":"2004780","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004780"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004780","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1584","698","329","1574"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"腸管および腎臓でのリン代謝におけるNpt2b欠損の影響","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Conditional deletion of Npt2b in phosphate transport","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"528","bibliographicPageStart":"517","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Nephrology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nHyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na+-dependent phosphate transporter Npt2b is thought to be an important molecular target for the prevention of hyperphosphatemia. The role of Npt2b in the net absorption of inorganic phosphate (Pi), however, is controversial.\nMethods\nIn the present study, we made tamoxifen-inducible Npt2b conditional knockout (CKO) mice to analyze systemic Pi metabolism, including intestinal Pi absorption.\nResults\nAlthough the Na+-dependent Pi transport in brush-border membrane vesicle uptake levels were significantly decreased in the distal intestine of Npt2b CKO mice compared with control mice, plasma Pi and fecal Pi excretion levels were not significantly different. Data obtained using the intestinal loop technique showed that Pi uptake in Npt2b CKO mice was not affected at a Pi concentration of 4 mM, which is considered the typical luminal Pi concentration after meals in mice. Claudin, which may be involved in paracellular pathways, as well as claudin-2, 12, and 15 protein levels were significantly decreased in the Npt2b CKO mice. Thus, Npt2b deficiency did not affect Pi absorption within the range of Pi concentrations that normally occurs after meals.\nConclusion\nThese findings indicate that abnormal Pi metabolism may also be involved in tight junction molecules such as Cldns that are affected by Npt2b deficiency.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Nephrology","subitem_publisher_language":"en"},{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© Japanese Society of Nephrology 2017\n","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13421751","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14377799","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11126935","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3139号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kayo Ikutaの学位論文として提出され，学位審査・授与の対象となっている。\nThis is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology.\nThe final publication is available at Springer via https://doi.org/10.1007/s10157-017-1497-3\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第248号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10157-017-1497-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-017-1497-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"342185"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"生田, かよ","creatorNameLang":"ja"},{"creatorName":"イクタ, カヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikuta, Kayo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"瀬川, 博子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ササキ, ショウヘイ","creatorNameLang":"ja"},{"creatorName":"ササキ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハナザキ, アイ","creatorNameLang":"ja"},{"creatorName":"ハナザキ, アイ","creatorNameLang":"ja-Kana"},{"creatorName":"Hanazaki, Ai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジイ, トオル","creatorNameLang":"ja"},{"creatorName":"フジイ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii, Toru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クシ, アオイ","creatorNameLang":"ja"},{"creatorName":"クシ, アオイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kushi, Aoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワバタ, ユウカ","creatorNameLang":"ja"},{"creatorName":"カワバタ, ユウカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawabata, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キリノ, ルリ","creatorNameLang":"ja"},{"creatorName":"キリノ, ルリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kirino, Ruri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササキ, スミレ","creatorNameLang":"ja"},{"creatorName":"ササキ, スミレ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Sumire","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノグチ, ミワ","creatorNameLang":"ja"},{"creatorName":"ノグチ, ミワ","creatorNameLang":"ja-Kana"},{"creatorName":"Noguchi, Miwa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"金子, 一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辰巳, 佐和子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウエダ, オトヤ","creatorNameLang":"ja"},{"creatorName":"ウエダ, オトヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Otoya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワダ, ナオコ","creatorNameLang":"ja"},{"creatorName":"ワダ, ナオコ","creatorNameLang":"ja-Kana"},{"creatorName":"Wada, Naoko A.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タテイシ, ヒロミ","creatorNameLang":"ja"},{"creatorName":"タテイシ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tateishi, Hiromi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カケフダ, マミ","creatorNameLang":"ja"},{"creatorName":"カケフダ, マミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kakefuda, Mami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワセ, ヨウスケ","creatorNameLang":"ja"},{"creatorName":"カワセ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawase, Yosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオトモ, シュウイチ","creatorNameLang":"ja"},{"creatorName":"オオトモ, シュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohtomo, Shuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イチダ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"イチダ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichida, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マエダ, アキラ","creatorNameLang":"ja"},{"creatorName":"マエダ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Maeda, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ジシャゲ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ジシャゲ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Jishage, Kou-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホリバ, ナオシ","creatorNameLang":"ja"},{"creatorName":"ホリバ, ナオシ","creatorNameLang":"ja-Kana"},{"creatorName":"Horiba, Naoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮本, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-06-19"}],"displaytype":"detail","filename":"k3139_abstract_review.pdf","filesize":[{"value":"288 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004780/files/k3139_abstract_review.pdf"},"version_id":"abbd240f-aa80-44d9-bf26-9dac9ed1ebc1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-05-20"}],"displaytype":"detail","filename":"k3139_fulltext.pdf","filesize":[{"value":"4.51 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004780/files/k3139_fulltext.pdf"},"version_id":"7b3b5033-ab6b-4117-b4a4-369ae78165ce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intestine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcellular transport-paracellular transport","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-19"},"publish_date":"2018-06-19","publish_status":"0","recid":"2004780","relation_version_is_last":true,"title":["Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T05:39:43.078728+00:00"}