{"created":"2024-10-28T05:46:14.091645+00:00","id":2004862,"links":{},"metadata":{"_buckets":{"deposit":"26c2da5d-0962-4926-b433-adb3ec6bd79f"},"_deposit":{"created_by":7,"id":"2004862","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004862"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004862","sets":["1713853213384:1713853295607"]},"author_link":["1648"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"A KINDRED OF MEN 2B","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"25","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Endocrinologia Japonica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We describe familial cases of multiple endocrine neoplasia (MEN) 2B: A 48-year-old man is the proband. He had pheochromocytoma, medullary thyroid carcinomas (MTCs), parathyroid hyperplasia, mucosal neuromas, eversion of eyelids and Marfanoid appearance, and then underwent adrenalectomy and total thyroidectomy. Family screening revealed that his two daughters (10 and 8 years old) had mucosal neuromas and increased serum calcitonin (CT). Both of them had MTCs but no pheochromocytoma, and their MTCs were surgically removed. The father and his children have been in favorable condition since the operations. Southern blot analysis with 33 polymorphic DNA probes was done in MTCs obtained from two daughters. An RBP3 (10q11.2) locus linked to a predisposing gene on chromosome 10 was uninformative in either patient because of constitutional homozygosity. Loss of heterozygosity at the MYCL1 locus on chromosome 1p32 was observed in MTC from the younger sister, but no loss of heterozygosity was recognized in other loci examined. Deletion of the 1p32 locus may play a role in the development of MEN 2B.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Endocrine Society","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"21856370","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"00137219","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00635052","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1507/endocrj1954.39.25"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1507/endocrj1954.39.25","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"71337"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヤマモト, シゲキ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, シゲキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Shigeki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリモト, イサオ","creatorNameLang":"ja"},{"creatorName":"モリモト, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Morimoto, Isao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジヒラ, タカシ","creatorNameLang":"ja"},{"creatorName":"フジヒラ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujihira, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ケンイチ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Kenichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ゼキ, カズヤ","creatorNameLang":"ja"},{"creatorName":"ゼキ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Zeki, Kazuya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]},{"creatorNames":[{"creatorName":"ゼゼ, フジオ","creatorNameLang":"ja"},{"creatorName":"ゼゼ, フジオ","creatorNameLang":"ja-Kana"},{"creatorName":"Zeze, Fujio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エトウ, スミヤ","creatorNameLang":"ja"},{"creatorName":"エトウ, スミヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Eto, Sumiya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"endocrj_39_1_25.pdf","filesize":[{"value":"1.39 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004862/files/endocrj_39_1_25.pdf"},"version_id":"6567d0f1-381c-40e1-a0d1-7e0ac2461a89"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Multiple endocrine neoplasia (MEN) 2B","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Medullary thyroid carcinoma (MTC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pheochromocytoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Kindred of Multiple Endocrine Neoplasia Type 2B","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Kindred of Multiple Endocrine Neoplasia Type 2B","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"2004862","relation_version_is_last":true,"title":["A Kindred of Multiple Endocrine Neoplasia Type 2B"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:55.680415+00:00"}