{"created":"2024-10-28T05:46:45.566070+00:00","id":2004868,"links":{},"metadata":{"_buckets":{"deposit":"edf854c4-a87c-4337-99d9-e7869ee43988"},"_deposit":{"created_by":7,"id":"2004868","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004868"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004868","sets":["1713853213384:1713853295607"]},"author_link":["174","1684","1648"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"RET MUTATIONS IN PHEOCHROMOCYTOMAS","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"114","bibliographicPageStart":"109","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Endocrine Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction (PCR) products and mutations in exon 13 by PCR-single strand conformation polymorphism (SSCP) analysis. Although mutations at codon 768 (GAG→GAC; Glu→Asp) of the RET proto-oncogene were recently reported to be found in 40% of sporadic medullary thyroid carcinomas (MTCs), the absence of missense mutations at codon 768 was confirmed both with PCR-restriction fragment length polymorphism (RFLP) and PCR-SSCP analysis in all examined cases of pheochromocytomas. These results suggest that mutations at codon 768 of the RET proto-oncogene do not represent a frequent mechanism of tumorigenesis for both sporadic and hereditary pheochromocytomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Endocrine 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proto-oncogene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Codon 768","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Exon 13","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pheochromocytoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Absence of Mutations at Codon 768 of the RET Proto-Oncogene in Sporadic and Hereditary Pheochromocytomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Absence of Mutations at Codon 768 of the RET Proto-Oncogene in 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