{"created":"2024-10-28T05:46:49.795871+00:00","id":2004869,"links":{},"metadata":{"_buckets":{"deposit":"302cfdcf-087c-46dc-9cfb-b528297d57b5"},"_deposit":{"created_by":7,"id":"2004869","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004869"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004869","sets":["1713853213384:1713853295607"]},"author_link":["174","1684","1648","1527"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"MUTATIONS OF RET AND GDNF GENES IN PITUITARY ADENOMAS","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"207","bibliographicPageStart":"199","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Endocrine Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RET is a receptor tyrosine kinase expressed in neuroendocrine cells and tumors. RET is activated by a ligand complex comprising glial cell line-derived neurotrophic factor (GDNF) and GDNF receptor-α (GDNFR-α). Activating mutations of the RET proto-oncogene were found in multiple endocrine neoplasia (MEN) 2 and in sporadic medullary thyroid carcinoma and pheochromocytoma of neuroendocrine origin. Mutations of the RET proto-oncogene and the glial cell line-derived neurotrophic factor (GDNF) gene were examined in human pituitary tumors. No mutations of the RET proto-oncogene including the cysteine-rich region or codon 768 and 918 in the tyrosine kinase domain were detected in 172 human pituitary adenomas either by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) or by PCR-restriction fragment length polymorphism (RFLP). Further, somatic mutations of the GDNF gene in 33 human pituitary adenomas were not detected by PCR-SSCP. One polymorphism of the GDNF gene at codon 145 of TGC or TGT was observed in a prolactinoma. The RET proto-oncogene message was detected in a normal human pituitary gland or 4 of 4 human pituitary adenomas with reverse transcription (RT)-PCR, and in rodent pituitary tumor cell lines with Western blotting. The expression of GDNF gene was detected in 1 of 4 human somatotroph adenomas, 1 of 2 corticotroph adenomas, and 2 of 6 rodent pituitary tumor cell lines with RT-PCR. Based on these, it is concluded that somatic mutations of the RET proto-oncogene or the GDNF gene do not appear to play a major role in the pituitary tumorigenesis in examined tumors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Endocrine 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adenomas","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"2004869","relation_version_is_last":true,"title":["Infrequent 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