{"created":"2024-10-28T05:46:58.671539+00:00","id":2004871,"links":{},"metadata":{"_buckets":{"deposit":"cb42cbaa-75aa-4d82-9703-4f66b57b95b2"},"_deposit":{"created_by":7,"id":"2004871","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004871"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004871","sets":["1713853213384:1713853295607"]},"author_link":["1648"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Characteristics in Multiple Endocrine Neoplasia Type 1 in Japan : A review of 106 patients","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"774","bibliographicPageStart":"764","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"日本内分泌学会雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Folia Endocrinologica Japonica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A review of 106 patients with multiple endocrine neoplasia (MEN) type 1 reported between 1966-1989 in Japan was conducted in order to clarify the natural history of this disease. Sporadic MEN 1 was found in 61 patients, and familial MEN 1 was found in 45 patients from 15 families. The mean ages at diagnosis of the two groups were 46.2 and 41.3 years, respectively, and the male to female ratio was 3:4.\nWith regards to the involvement of the pituitary, parathyroid and endocrine pancreas, the combination of three endocrine glands was 31%, and that of two was 48%, in which the pituitary, parathyroid and endocrine pancreas had tumorous lesions in 60%, 88% and 63%, respectively.\nThe first clinical manifestations of MEN 1 were the symptoms of hyperparathyroidism (32%), pituitary tumors (26%), peptic ulcer (28%) and hypoglycemia (13%). These symptoms appeared between 6 and 57 years of age (mean 34 years). The main clinical symptoms of the pituitary tumors were acromegaly and gigantism (37%), galactorrhea-amenorrhea syndrome (20%), Cushing's disease (10%) and visual disturbance due to compression of the tumor (20%). The clinical manifestations of hyperparathyroidism were mainly asymptomatic hypercalcemia (41%), nephrolithiasis (42%) and osteitis fibrosa (5%). In the patients with pancreatic tumor, Zollinger-Ellison syndrome (52%) and hypoglycemic symptoms (42%) were found. Tumors in the adrenal cortex, thyroid, carcinoid and lipoma were detected in association with MEN 1 in the frequencies of 28%, 21%, 9% and 5%, respectively.\nDeath was reported in 37 patients between 9 and 86 years of age (mean 50.0 years). The cause of death was gastrointestinal bleeding and perforation (45%), surgery (24%) and disseminated carcinomatosis (18%).\nRecently, the gene predisposing to this syndrome has been assigned to chromosome 11 (11q13) in non-Japanese cases but not yet in Japanese MEN 1 patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"一般社団法人 日本内分泌学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2186506X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"00290661","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00195891","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1507/endocrine1927.67.7_764"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1507/endocrine1927.67.7_764","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"71582"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]},{"creatorNames":[{"creatorName":"斎藤, 史郎","creatorNameLang":"ja"},{"creatorName":"サイトウ, シロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Shiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"endocrine_67_7_764.pdf","filesize":[{"value":"1.06 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004871/files/endocrine_67_7_764.pdf"},"version_id":"e31b9c36-1457-474e-bd56-ef53fe5e744d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"本邦における多発性内分泌腺腫瘍症1型の実態調査","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"本邦における多発性内分泌腺腫瘍症1型の実態調査","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"2004871","relation_version_is_last":true,"title":["本邦における多発性内分泌腺腫瘍症1型の実態調査"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:21.459845+00:00"}