{"created":"2024-10-28T05:54:49.650273+00:00","id":2004973,"links":{},"metadata":{"_buckets":{"deposit":"2d8b021e-b420-45a2-842d-269348462822"},"_deposit":{"created_by":7,"id":"2004973","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004973"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004973","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["418","810","1546","1548","519","960","316"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"DDX31/p53変異/EGFR経路は筋層浸潤膀胱癌の多段階進展を促進する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Critical roles of DDX31-mutp53-EGFR axis in MIBC progression","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2247","bibliographicPageStart":"2233","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"Cancer Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The p53 and EGFR pathways are frequently altered in bladder cancers, yet their contributions to its progression remain elusive. Here we report that DEAD box polypeptide 31 (DDX31) plays a critical role in the multistep progression of muscle invasive bladder cancer (MIBC) through its sequential interactions with mutant p53 (mutp53) and EGFR. In early MIBC cells, nuclear DDX31 bound mutp53/SP1 and enhanced mutp53 transcriptional activation, leading to migration and invasion of MIBC. Cytoplasmic DDX31 also bound EGFR and phospho-nucleolin (p-NCL) in advanced MIBC, leading to EGFR-Akt signaling activation. High expression of both cytoplasmic DDX31 and p53 proteins correlated with poor prognosis in patients with MIBC, and blocking the DDX31-NCL interaction resulted in downregulation of EGFR-Akt signaling, eliciting an in vivo anti-tumor effect against bladder cancer. These findings reveal that DDX31 cooperates with mutp53 and EGFR to promote progression of MIBC, and inhibition of DDX31-NCL formation may lead to potential treatment strategies for advanced MIBC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for Cancer Research","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00085472","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15387445","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12004911","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00598557","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3194号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-04-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1371号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1158/0008-5472.CAN-17-2528"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1158/0008-5472.CAN-17-2528","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"338903"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大豆本, 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promotes multistep progression of muscle invasive bladder cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"2004973","relation_version_is_last":true,"title":["A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T13:34:56.609439+00:00"}