{"created":"2024-10-28T06:00:48.417326+00:00","id":2005051,"links":{},"metadata":{"_buckets":{"deposit":"82419344-6cec-44db-b88a-c1d0813aa59f"},"_deposit":{"created_by":7,"id":"2005051","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005051"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005051","sets":["1713853213384:1713853295607"]},"author_link":["1197","121"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"540","bibliographicPageStart":"534","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"Bioscience, Biotechnology, and Biochemistry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis. Alisol B suppressed mRNA induction of tyrosinase and its transcription factor, microphthalmia-associated transcription factor (MITF). Furthermore, alisol B reduced the phosphorylation of CREB and maintained the activation of ERK1/2. These results suggest that the reduction in melanin production by alisol B is due to the downregulation of MITF through the suppression of CREB and activation of ERK, and that alisol B may be useful as a new whitening agent.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society for Bioscience, Biotechnology, and Agrochemistry","subitem_publisher_language":"en"},{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09168451","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13476947","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10824164","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is an electronic version of an article published in Bioscience, Biotechnology, and Biochemistry 81, 3, 534-540, 2017. Bioscience, Biotechnology, and Biochemistry is available online at: www.tandfonline.com/10.1080/09168451.2016.1268042."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/09168451.2016.1268042"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09168451.2016.1268042","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"322768"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヨシダ, イチロウ","creatorNameLang":"ja"},{"creatorName":"ヨシダ, イチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, チヒロ","creatorNameLang":"ja"},{"creatorName":"イトウ, チヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Chihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツダ, シンヤ","creatorNameLang":"ja"},{"creatorName":"マツダ, シンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Shinya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"辻, 明彦","creatorNameLang":"ja"},{"creatorName":"ツジ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuji, Akihiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"辻","familyNameLang":"ja"},{"familyName":"ツジ","familyNameLang":"ja-Kana"},{"familyName":"Tsuji","familyNameLang":"en"}],"givenNames":[{"givenName":"明彦","givenNameLang":"ja"},{"givenName":"アキヒコ","givenNameLang":"ja-Kana"},{"givenName":"Akihiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"121","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10788/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10788/profile-ja.html"},{"nameIdentifier":"20155360","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20155360"}]},{"creatorNames":[{"creatorName":"ヤナカ, ノリユキ","creatorNameLang":"ja"},{"creatorName":"ヤナカ, ノリユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanaka, Noriyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"湯浅, 恵造","creatorNameLang":"ja"},{"creatorName":"ユアサ, ケイゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yuasa, Keizo","creatorNameLang":"en"}],"familyNames":[{"familyName":"湯浅","familyNameLang":"ja"},{"familyName":"ユアサ","familyNameLang":"ja-Kana"},{"familyName":"Yuasa","familyNameLang":"en"}],"givenNames":[{"givenName":"恵造","givenNameLang":"ja"},{"givenName":"ケイゾウ","givenNameLang":"ja-Kana"},{"givenName":"Keizo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1197","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70363132","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70363132"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-07-03"}],"displaytype":"detail","filename":"bbb_81_3_534.pdf","filesize":[{"value":"521 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(MITF)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-03"},"publish_date":"2018-07-03","publish_status":"0","recid":"2005051","relation_version_is_last":true,"title":["Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T05:29:41.990773+00:00"}