{"created":"2024-10-28T06:03:22.820488+00:00","id":2005078,"links":{},"metadata":{"_buckets":{"deposit":"6adb2244-265a-459d-811f-78a3891af0c4"},"_deposit":{"created_by":7,"id":"2005078","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005078"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005078","sets":["1713853213384:1713853295607"]},"author_link":["232","1567","514","228","188"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"971","bibliographicPageStart":"968","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"ChemBioChem","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Utilization of a hypoxia-responsive amino acid is indispensable in the preparation of hypoxic tumor-specific peptidyl prodrugs. Bioreduction of a nitro group is among the most attractive triggering reactions in the hypoxia-responsive prodrugs. In this paper, design and synthesis of a reduction-responsive amino acid that induces peptide bond cleavage after reduction of the nitro group are described. Application to hypoxia-responsive peptide bond cleavage system is also reported.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY‐VCH Verlag GmbH & Co. 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(2012), Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells. ChemBioChem, 13: 968-971. doi:10.1002/cbic.201200141, which has been published in final form at https://doi.org/10.1002/cbic.201200141. 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