{"created":"2024-10-28T06:09:05.783517+00:00","id":2005153,"links":{},"metadata":{"_buckets":{"deposit":"5f816723-aee9-4919-b021-2a9d2f62b8d6"},"_deposit":{"created_by":7,"id":"2005153","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005153"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005153","sets":["1713853213384:1713853295607"]},"author_link":["1018","1036"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"149","bibliographicPageStart":"145","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Toxicology in Vitro","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the effects of dibromoacetonitrile (DBAN), a by-product in water bacterial control, at sublethal concentrations on rat thymocytes, by using a cytometric technique with appropriate fluorescent dyes. By using this method, the possibility that DBAN induces cellular actions related to oxidative stress was assessed. DBAN reduced the content of cellular nonprotein thiols under Zn2+-free conditions. It elevated the intracellular level of Zn2+, being independent from external Zn2+. DBAN increased cell vulnerability to the cytotoxic action of hydrogen peroxide. These actions of DBAN were likely related to oxidative stress. DBAN is formed by the reaction of bromides and chlorinated oxidants during water disinfection. Hydrolysis of 2,2-dibromo-3-nitrilopropionamide, an antimicrobial used in hydraulic fracturing fluids for production of shale gas and oil, produces DBAN. Therefore, the concern regarding the levels of DBAN in industrial water systems is necessary to avoid the environmental risk to humans and wild mammals.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"08872333","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10678594","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11540107","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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level","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"2005153","relation_version_is_last":true,"title":["Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T06:46:11.388167+00:00"}