| Item type |
文献 / Documents(1) |
| 公開日 |
2018-08-06 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.prostaglandins.2018.01.003 |
|
|
関連名称 |
10.1016/j.prostaglandins.2018.01.003 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro |
| 著者 |
Afroz, Sheuli
ヤギ, アヤノ
フジカワ, コウキ
Rahman, M. Motiur
モリト, カツヤ
福田, 達也
ワタナベ, シロウ
キヨカゲ, エミ
トイダ, カズノリ
清水, 太郎
石田, 竜弘
小暮, 健太朗
德村, 彰
田中, 保
|
| 抄録 |
|
|
内容記述 |
Lysophosphatidic acid (LPA) is a bioactive phospholipid that induces diverse biological responses. Recently, we found that LPA ameliorates NSAIDs-induced gastric ulcer in mice. Here, we quantified LPA in 21 medicinal herbs used for treatment of gastrointestinal (GI) disorders. We found that half of them contained LPA at relatively high levels (40–240 μg/g) compared to soybean seed powder (4.6 μg/g), which we previously identified as an LPA-rich food. The LPA in peony (Paeonia lactiflora) root powder is highly concentrated in the lipid fraction that ameliorates indomethacin-induced gastric ulcer in mice. Synthetic 18:1 LPA, peony root LPA and peony root lipid enhanced prostaglandin E2 production in a gastric cancer cell line, MKN74 cells that express LPA2 abundantly. These materials also prevented indomethacin-induced cell death and stimulated the proliferation of MKN74 cells. We found that LPA was present in stomach fluids at 2.4 μM, which is an effective LPA concentration for inducing a cellular response in vitro. These results indicated that LPA is one of the active components of medicinal herbs for the treatment of GI disorder and that orally administered LPA-rich herbs may augment the protective actions of endogenous LPA on gastric mucosa. |
| キーワード |
|
|
主題 |
Lysophosphatidic acid |
| キーワード |
|
|
主題 |
Medicinal herbs |
| キーワード |
|
|
主題 |
Indomethacin |
| キーワード |
|
|
主題 |
Prostaglandin E2 |
| キーワード |
|
|
主題 |
Cell death |
| キーワード |
|
|
主題 |
Cell proliferation |
| 書誌情報 |
en : Prostaglandins & Other Lipid Mediators
巻 135,
p. 36-44,
発行日 2018-02-17
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10988823 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11221062 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11532903 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
339054 |
| 言語 |
|
|
言語 |
eng |
polm_135_36.pdf (1.7 MB)
