{"created":"2024-10-28T06:12:36.174610+00:00","id":2005198,"links":{},"metadata":{"_buckets":{"deposit":"dec594fe-22c2-4064-8d9e-7c22e9ef60bd"},"_deposit":{"created_by":7,"id":"2005198","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005198"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005198","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["887","193","265","1266","295","603","702","517","792","845","885","886","1253"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"肝細胞癌患者における術前血清CEA値上昇は上皮間葉転換を介して予後不良と関連する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Elevated Preoperative Serum CEA Level Is with Hepatocellular Carcinoma with Poor Prognosis Through the Epithelial-Mesenchymal Transition","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1175","bibliographicPageStart":"1169","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Anticancer Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial–mesenchymal transition (EMT) and tumor angiogenesis. Materials and Methods: One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. Results: In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Conclusion: Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"02507005","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17917530","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10625860","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12440673","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3204号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-07-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者MASATO YOSHIKAWAの学位論文として提出され, 学位審査・授与の対象となっている。\n公開に関する許諾確認は著者・編集事務局間のメールによる。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1379号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.21873/anticanres.11430"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.11430","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"330329"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉川, 雅登","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池本, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"居村, 暁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東島, 潤","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩橋, 衆一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙須, 千絵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 眞一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川, 大地","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺奥, 大貴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙田, 厚史","creatorNameLang":"ja"},{"creatorName":"タカタ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"良元, 俊昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-08-28"}],"displaytype":"detail","filename":"k3204_review_abstract.pdf","filesize":[{"value":"371 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2005198/files/k3204_review_abstract.pdf"},"version_id":"257a3068-51e3-45a5-9c03-fa3b722f68d7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-08-28"}],"displaytype":"detail","filename":"k3204_fulltext.pdf","filesize":[{"value":"6.57 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