{"created":"2024-10-28T06:20:34.657688+00:00","id":2005307,"links":{},"metadata":{"_buckets":{"deposit":"2ea74540-10f9-4af9-a8c4-b7eef4691698"},"_deposit":{"created_by":7,"id":"2005307","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005307"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005307","sets":["1713829974766:1713854682253:1716422256715:1716425245380","1713853213384:1713853295607"]},"author_link":["1224","1591","1635"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"高Lp（a）血症におけるaspirinの効果","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Effect of aspirin treatment on serum levels of lipoprotein (a) : analysis from the apolipoprotein (a) isoforms","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"114","bibliographicPageStart":"109","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Shikoku Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have found that aspirin lowers elevated serum lipoprotein(a) [Lp(a)] levels via reduction of the transcriptional activity of apolipoprotein(a) [apo(a)] gene with suppression of apo(a) mRNA expression. In the present study, we evaluated the effect of aspirin treatment on serum Lp(a) level and analyzed its relation to type of apo(a) isoform. Serum levels of Lp(a) were measured by turbidimetric immunoassay before and after the oral administration of aspirin therapy (81 mg/day) in 57 patients with coronary artery disease or cerebral infarction. Apo(a) isoforms were determined by immunoblotting method. In patients with high serum Lp(a) levels (more than 30 mg/dl), aspirin reduced serum Lp(a) levels to approximately 80 % of the baseline after one month. Their levels sustained significantly low even after six months. The effect of aspirin in reducing elevated serum Lp(a) levels were stronger in patients with smaller-sized type or double-band type of apo(a) isoforms. The transcriptional efficiency of apo(a) gene is thought to be increased in patients with these apo(a) isoforms. Therefore, these findings suggest that aspirin reduces apo(a) gene transcription preferentialy in patients with high transcriptional efficiency of this gene.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"136183"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"赤池, 雅史","creatorNameLang":"ja"},{"creatorName":"アカイケ, マサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Akaike, Masashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"赤池","familyNameLang":"ja"},{"familyName":"アカイケ","familyNameLang":"ja-Kana"},{"familyName":"Akaike","familyNameLang":"en"}],"givenNames":[{"givenName":"雅史","givenNameLang":"ja"},{"givenName":"マサシ","givenNameLang":"ja-Kana"},{"givenName":"Masashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1635","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60267/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60267/profile-ja.html"},{"nameIdentifier":"90271080","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90271080"}]},{"creatorNames":[{"creatorName":"東, 博之","creatorNameLang":"ja"},{"creatorName":"アズマ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuma, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香川, 礼香","creatorNameLang":"ja"},{"creatorName":"カガワ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagawa, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"金川, 泰彦","creatorNameLang":"ja"},{"creatorName":"カナガワ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanagawa, Yasuhiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"粟飯原, 賢一","creatorNameLang":"ja"},{"creatorName":"アイハラ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Aihara, Ken-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"粟飯原","familyNameLang":"ja"},{"familyName":"アイハラ","familyNameLang":"ja-Kana"},{"familyName":"Aihara","familyNameLang":"en"}],"givenNames":[{"givenName":"賢一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Ken-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1224","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"75205/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/75205/profile-ja.html"},{"nameIdentifier":"70372711","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70372711"}]},{"creatorNames":[{"creatorName":"松山, まどか","creatorNameLang":"ja"},{"creatorName":"マツヤマ, マドカ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuyama, Madoka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井内, 貴彦","creatorNameLang":"ja"},{"creatorName":"イウチ, タカヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Iuchi, Takahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高森, 信行","creatorNameLang":"ja"},{"creatorName":"タカモリ, ノブユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takamori, Nobuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 智則","creatorNameLang":"ja"},{"creatorName":"ヨシダ, トモノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Tomonori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 俊夫","creatorNameLang":"ja"},{"creatorName":"マツモト, トシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"俊夫","givenNameLang":"ja"},{"givenName":"トシオ","givenNameLang":"ja-Kana"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1591","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60162/profile-ja.html"},{"nameIdentifier":"20157374","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20157374"}]},{"creatorNames":[{"creatorName":"松本, 和也","creatorNameLang":"ja"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Kazuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"林, 郁郎","creatorNameLang":"ja"},{"creatorName":"ハヤシ, イクロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Ikuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田村, 克也","creatorNameLang":"ja"},{"creatorName":"タムラ, カツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Katsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"西内, 健","creatorNameLang":"ja"},{"creatorName":"ニシウチ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishiuchi, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-09-10"}],"displaytype":"detail","filename":"sam_55_3_109.PDF","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005307/files/sam_55_3_109.PDF"},"version_id":"de40d2c1-c6b5-4ae3-942f-77d62a7a4479"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lipoprotein (a)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apolipoprotein (a)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aspirin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apo(a) isoform","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lp(a) phenotype","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"高リポ蛋白(a)血症に及ぼすaspirinの影響 : アポリポ蛋白(a)アイソフォームとの関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高リポ蛋白(a)血症に及ぼすaspirinの影響 : アポリポ蛋白(a)アイソフォームとの関連","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716425245380"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-10"},"publish_date":"2018-09-10","publish_status":"0","recid":"2005307","relation_version_is_last":true,"title":["高リポ蛋白(a)血症に及ぼすaspirinの影響 : アポリポ蛋白(a)アイソフォームとの関連"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T00:07:15.241444+00:00"}