{"created":"2024-10-28T06:24:34.044073+00:00","id":2005363,"links":{},"metadata":{"_buckets":{"deposit":"c9036b96-2b08-43e1-b4fe-22b00376a3e8"},"_deposit":{"created_by":7,"id":"2005363","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005363"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005363","sets":["1713853213384:1713853295607"]},"author_link":["307","220"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Prion protein in virus infections","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"811","bibliographicPageStart":"808","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"DNA and Cell Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The normal cellular prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrPC has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The anti-oxidative activity of PrPC is probably attributable to its function to activate anti-oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs. Oxidative stress could play a pivotal role in the pathogenesis of a wide range of viral infections. Here, we introduce our and others’ studies on the role of PrPC in viral infections, and raise the attractive possibility that PrPC might be a novel target molecule for development of anti-oxidative therapeutics against not only IAV infection but also other viral infections.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert, Inc.","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10445498","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15577430","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10747642","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/dna.2018.4402"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1089/dna.2018.4402"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1089/dna.2018.4402","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"356502"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂口, 末廣","creatorNameLang":"ja"},{"creatorName":"サカグチ, スエヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakaguchi, Suehiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂口","familyNameLang":"ja"},{"familyName":"サカグチ","familyNameLang":"ja-Kana"},{"familyName":"Sakaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"末廣","givenNameLang":"ja"},{"givenName":"スエヒロ","givenNameLang":"ja-Kana"},{"givenName":"Suehiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"220","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"140706/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/140706/profile-ja.html"},{"nameIdentifier":"60274635","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60274635"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"千田, 淳司","creatorNameLang":"ja"},{"creatorName":"チダ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Chida, Junji","creatorNameLang":"en"}],"familyNames":[{"familyName":"千田","familyNameLang":"ja"},{"familyName":"チダ","familyNameLang":"ja-Kana"},{"familyName":"Chida","familyNameLang":"en"}],"givenNames":[{"givenName":"淳司","givenNameLang":"ja"},{"givenName":"ジュンジ","givenNameLang":"ja-Kana"},{"givenName":"Junji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"307","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172448/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172448/profile-ja.html"},{"nameIdentifier":"20437651","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20437651"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-10-04"}],"displaytype":"detail","filename":"dna_37_10_808.pdf","filesize":[{"value":"748 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005363/files/dna_37_10_808.pdf"},"version_id":"84cc7849-0a31-4934-b448-48936e63e0b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prion protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"influenza A virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"superoxide dismutase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"copper","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Roles of Prion Protein in Virus Infections","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Roles of Prion Protein in Virus Infections","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-10-05"},"publish_date":"2018-10-05","publish_status":"0","recid":"2005363","relation_version_is_last":true,"title":["Roles of Prion Protein in Virus Infections"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T04:54:05.671375+00:00"}