{"created":"2024-10-28T07:34:44.249850+00:00","id":2005514,"links":{},"metadata":{"_buckets":{"deposit":"32cf165d-0861-4df9-b3c9-5d08666e64d1"},"_deposit":{"created_by":7,"id":"2005514","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005514"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005514","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["536","1564","1589","796","1631"],"control_number":"2005514","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"アスペルガー症候群におけるMRSを用いた前部帯状回と小脳の機能評価","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"MRS Study of ACC in Asperger's Syndrome","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e0169288","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose\nProton magnetic resonance spectroscopy (1H MRS) is a noninvasive neuroimaging method to quantify biochemical metabolites in vivo and it can serve as a powerful tool to monitor neurobiochemical profiles in the brain. Asperger's syndrome (AS) is a type of autism spectrum disorder, which is characterized by impaired social skills and restrictive, repetitive patterns of interest and activities, while intellectual levels and language skills are relatively preserved. Despite clinical aspects have been well-characterized, neurometabolic profiling in the brain of AS remains to be clear. The present study used proton magnetic resonance spectroscopy (1H MRS) to investigate whether pediatric AS is associated with measurable neurometabolic abnormalities that can contribute new information on the neurobiological underpinnings of the disorder.\n\nMethods\nStudy participants consisted of 34 children with AS (2-12 years old; mean age 5.2 (±2.0); 28 boys) and 19 typically developed children (2-11 years old; mean age 5.6 (±2.6); 12 boys) who served as the normal control group. The 1H MRS data were obtained from two regions of interest: the anterior cingulate cortex (ACC) and left cerebellum.\n\nResults\nIn the ACC, levels of N-acetylaspartate (NAA), total creatine (tCr), total choline-containing compounds (tCho) and myo-Inositol (mI) were significantly decreased in children with AS compared to controls. On the other hand, no significant group differences in any of the metabolites were found in the left cerebellum. Neither age nor sex accounted for the metabolic findings in the regions.\n\nConclusion\nThe finding of decreased levels of NAA, tCr, tCho, and mI in the ACC but not in left cerebellar voxels in the AS, suggests a lower ACC neuronal density in the present AS cohort compared to controls.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2017 Goji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3012号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨・審査要旨：LID201704131001.pdf\n論文本文：LID201704131002.pdf\n本論文は，著者Aya Gojiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1316号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1371/journal.pone.0169288"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0169288","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"341744"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"郷司, 彩","creatorNameLang":"ja"},{"creatorName":"ゴウジ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Goji, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊藤, 弘道","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 健治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田, 雅史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒサオカ, ソノカ","creatorNameLang":"ja"},{"creatorName":"ヒサオカ, ソノカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisaoka, Sonoka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"東田, 好広","creatorNameLang":"ja"},{"creatorName":"トウダ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Toda, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"森, 達夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"アベ, ヨウコ","creatorNameLang":"ja"},{"creatorName":"アベ, ヨウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Yoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤザキ, マサヒト","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, マサヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazaki, Masahito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香美, 祥二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1631","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-14"}],"displaytype":"detail","filename":"LID201704131001.pdf","filesize":[{"value":"312 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2005514/files/LID201704131001.pdf"},"version_id":"f3e3f815-7b4d-42de-87e0-894419635980"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-14"}],"displaytype":"detail","filename":"LID201704131002.pdf","filesize":[{"value":"264 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005514/files/LID201704131002.pdf"},"version_id":"97eae9e9-2965-4885-925f-73edb5f4f913"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Asperger's Syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Magnetic Resonance Spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anterior Cingulate Cortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Assessment of Anterior Cingulate Cortex (ACC) and Left Cerebellar Metabolism in Asperger's Syndrome with Proton Magnetic Resonance Spectroscopy (MRS)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of Anterior Cingulate Cortex (ACC) and Left Cerebellar Metabolism in Asperger's Syndrome with Proton Magnetic Resonance Spectroscopy (MRS)","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005514","relation_version_is_last":true,"title":["Assessment of Anterior Cingulate Cortex (ACC) and Left Cerebellar Metabolism in Asperger's Syndrome with Proton Magnetic Resonance Spectroscopy (MRS)"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-25T04:43:10.700400+00:00"}