| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2018-11-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3390/ijms17101638 |
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関連名称 |
10.3390/ijms17101638 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Homeodomain-Interacting Protein Kinase-2 : A Critical Regulator of the DNA Damage Response and the Epigenome |
| 著者 |
桑野, 由紀
西田, 憲生
アカイケ, ヨウコ
クロカワ, ケン
西川, 達哉
増田, 清士
六反, 一仁
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| 抄録 |
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内容記述 |
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. Maintenance of the DDR is essential to prevent development of diseases caused by genomic instability, including cancer, defects of development, and neurodegenerative disorders. Recent studies reveal a novel HIPK2-mediated pathway for DDR through interaction with chromatin remodeling factor homeodomain protein 1γ. In this review, we will highlight the molecular mechanisms of HIPK2 and show its functions as a crucial DDR regulator. |
| キーワード |
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主題 |
DNA damage responses |
| キーワード |
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主題 |
HIPK2 |
| キーワード |
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主題 |
HP1γ |
| キーワード |
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主題 |
cell cycle |
| キーワード |
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主題 |
apoptosis |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 17,
号 10,
p. 1638,
発行日 2016-09-27
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14220067 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
16616596 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12038549 |
| 出版者 |
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出版者 |
MDPI |
| 権利情報 |
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権利情報 |
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
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識別子 |
327366 |
| 言語 |
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言語 |
eng |
ijms_17_10_1638.pdf (951 KB)
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