{"created":"2024-10-28T07:38:56.069535+00:00","id":2005560,"links":{},"metadata":{"_buckets":{"deposit":"09826c06-1afe-4461-9bb8-2811d2407831"},"_deposit":{"created_by":7,"id":"2005560","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005560"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005560","sets":["1713853213384:1713853295607"]},"author_link":["1542","209"],"control_number":"2005560","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"98","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An adequate blood supply is essential for cancer cells to survive and grow; thus, the concept of inhibiting tumor angiogenesis has been applied to cancer therapy, and several drugs are already in clinical use. It has been shown that treatment with those anti-angiogenic drugs improved the response rate and prolonged the survival of patients with various types of cancer; however, it is also true that the effect was mostly limited. Currently, the disappointing clinical results are explained by the existence of intrinsic or acquired resistance to the therapy mediated by both tumor cells and stromal cells. This article reviews the mechanisms of resistance mediated by stromal cells such as endothelial cells, pericytes, fibroblasts and myeloid cells, with an emphasis on fibrocytes, which were recently identified as the cell type responsible for regulating acquired resistance to anti-angiogenic therapy. In addition, the other emerging role of fibrocytes as mediator-producing cells in tumor progression is discussed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16616596","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms19010098"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms19010098","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"338635"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"後東, 久嗣","creatorNameLang":"ja"},{"creatorName":"ゴトウ, ヒサツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Goto, Hisatsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"後東","familyNameLang":"ja"},{"familyName":"ゴトウ","familyNameLang":"ja-Kana"},{"familyName":"Goto","familyNameLang":"en"}],"givenNames":[{"givenName":"久嗣","givenNameLang":"ja"},{"givenName":"ヒサツグ","givenNameLang":"ja-Kana"},{"givenName":"Hisatsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"209","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00437641","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00437641"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"ijms_19_1_98.pdf","filesize":[{"value":"521 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005560/files/ijms_19_1_98.pdf"},"version_id":"be7f56a4-adef-407e-895f-772b550a97f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-angiogenic therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor stroma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fibrocytes : A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fibrocytes : A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005560","relation_version_is_last":true,"title":["Fibrocytes : A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:19:15.872158+00:00"}