{"created":"2024-10-28T07:39:08.374437+00:00","id":2005562,"links":{},"metadata":{"_buckets":{"deposit":"18d0f257-4b83-4890-b4a7-0b8069b68b0d"},"_deposit":{"created_by":7,"id":"2005562","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005562"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005562","sets":["1713853213384:1713853295607"]},"author_link":["813","1721","572"],"control_number":"2005562","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"1462","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)—the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood. These topics continue to be very active fields of cancer research. A number of processes, factors, and signaling pathways are involved in regulating invasion and metastasis. However, appropriate clinical trials for anti-cancer drugs targeting the invasion of OSCC are incomplete. In this review, we summarize the recent progress on invasion-related factors and emerging molecular determinants which can be used as potential for diagnostic and therapeutic targets in OSCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16616596","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms19051462"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms19051462","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"340882"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Siriwardena, Samadarani B. S. M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qi, Guangying","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石丸, 直澄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"工藤, 保誠","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"572","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-09"}],"displaytype":"detail","filename":"ijms_19_5_1462.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://tokushima-u.repo.nii.ac.jp/record/2005562/files/ijms_19_5_1462.pdf"},"version_id":"b3f15aff-037a-4311-bd56-5477a8694db7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oral squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial mesenchymal transition (EMT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell adhesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor microenvironment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma : A Review","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma : A Review","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005562","relation_version_is_last":true,"title":["Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma : A Review"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-18T04:09:34.641588+00:00"}