{"created":"2024-10-28T07:40:58.002522+00:00","id":2005585,"links":{},"metadata":{"_buckets":{"deposit":"4af0f20b-276a-46e4-95d6-a15536fd5203"},"_deposit":{"created_by":7,"id":"2005585","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005585"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005585","sets":["1713853213384:1713853295607"]},"author_link":["306"],"control_number":"2005585","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10594","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intracellular trafficking of receptor proteins is essential for neurons to detect various extracellular factors during the formation and refinement of neural circuits. However, the precise mechanisms underlying the trafficking of neurotrophin receptors to synapses remain elusive. Here, we demonstrate that a brain-enriched sorting nexin, ARHGAP33, is a new type of regulator for the intracellular trafficking of TrkB, a high-affinity receptor for brain-derived neurotrophic factor. ARHGAP33 knockout (KO) mice exhibit reduced expression of synaptic TrkB, impaired spine development and neuropsychiatric disorder-related behavioural abnormalities. These deficits are rescued by specific pharmacological enhancement of TrkB signalling in ARHGAP33 KO mice. Mechanistically, ARHGAP33 interacts with SORT1 to cooperatively regulate TrkB trafficking. Human ARHGAP33 is associated with brain phenotypes and reduced SORT1 expression is found in patients with schizophrenia. We propose that ARHGAP33/SORT1-mediated TrkB trafficking is essential for synapse development and that the dysfunction of this mechanism may be a new molecular pathology of neuropsychiatric disorders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Supplementary Information : ncomms_7_10594_s1.pdf\nCorrigendum : https://doi.org/10.1038/ncomms11466"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/ncomms10594"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/ncomms10594","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"307654"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナカザワ, タカノブ","creatorNameLang":"ja"},{"creatorName":"ナカザワ, タカノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazawa, Takanobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, 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タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨコヤマ, カズマサ","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, カズマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Kazumasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, タカフミ","creatorNameLang":"ja"},{"creatorName":"イノウエ, タカフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Takafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"沼田, 周助","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オオヌマ, トオル","creatorNameLang":"ja"},{"creatorName":"オオヌマ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnuma, Tohru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワタ, ナカオ","creatorNameLang":"ja"},{"creatorName":"イワタ, ナカオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, 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