{"created":"2024-10-28T07:41:03.053937+00:00","id":2005586,"links":{},"metadata":{"_buckets":{"deposit":"bcef796f-58fc-4252-a7b1-268e8636c54d"},"_deposit":{"created_by":7,"id":"2005586","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005586"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005586","sets":["1713853213384:1713853295607"]},"author_link":["479"],"control_number":"2005586","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"15141","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Leptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of β2-adrenergic receptor (AR), the major β-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle. Leptin-induced 2DG uptake was not observed in β-AR-deficient (β-less) mice despite that AMPK phosphorylation was increased in the muscle. Forced expression of β2-AR in the unilateral hind limb of β-less mice restored leptin-induced glucose uptake and enhancement of insulin signalling in red-type skeletal muscle. Leptin increased 2DG uptake and enhanced insulin signalling in red-type skeletal muscle of mice expressing a dominant negative form of AMPK (DN-AMPK) in skeletal muscle. Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and β2-AR in muscle and in a manner independent of muscle AMPK.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Supplementary Information : srep_7_15141_s1.pdf"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-017-15548-6"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-017-15548-6","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"343501"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"志内, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"トダ, チトク","creatorNameLang":"ja"},{"creatorName":"トダ, チトク","creatorNameLang":"ja-Kana"},{"creatorName":"Toda, Chitoku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカモト, シキ","creatorNameLang":"ja"},{"creatorName":"オカモト, シキ","creatorNameLang":"ja-Kana"},{"creatorName":"Okamoto, Shiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Coutinho, Eulalia A.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サイトウ, クミコ","creatorNameLang":"ja"},{"creatorName":"サイトウ, クミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Kumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, シンジ","creatorNameLang":"ja"},{"creatorName":"ミウラ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エザキ, オサム","creatorNameLang":"ja"},{"creatorName":"エザキ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Ezaki, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミノコシ, ヤスヒコ","creatorNameLang":"ja"},{"creatorName":"ミノコシ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Minokoshi, Yasuhiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"srep_7_15141.pdf","filesize":[{"value":"1.76 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005586/files/srep_7_15141.pdf"},"version_id":"c8e0c46a-ea5c-4e75-b918-e2e816d5347c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"srep_7_15141_s1.pdf","filesize":[{"value":"733 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005586/files/srep_7_15141_s1.pdf"},"version_id":"c4832973-0cbe-4ce0-8197-be4e99498d2d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005586","relation_version_is_last":true,"title":["Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-16T02:27:01.036824+00:00"}