{"created":"2024-10-28T07:41:08.453807+00:00","id":2005587,"links":{},"metadata":{"_buckets":{"deposit":"4796cd8a-67a4-4549-a1da-e8d507c6f6c0"},"_deposit":{"created_by":7,"id":"2005587","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005587"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005587","sets":["1713853213384:1713853295607"]},"author_link":["653","1248"],"control_number":"2005587","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1493","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12–13 and 5q33.3) that met suggestive significance (P < 1 × 10−6). In the replication stage (n = 4,949), the lead variant for the 12q24.12–13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10−6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10−16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2018 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Supplementary Information : srep_8_1493_s1.pdf"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-018-19914-w"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-018-19914-w","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"339856"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナカガワ センダ, ヒロコ","creatorNameLang":"ja"},{"creatorName":"ナカガワ センダ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa-Senda, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハチヤ, ツヨシ","creatorNameLang":"ja"},{"creatorName":"ハチヤ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hachiya, 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ケンジ","creatorNameLang":"ja"},{"creatorName":"ワカイ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Wakai, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モモザワ, ユキヒデ","creatorNameLang":"ja"},{"creatorName":"モモザワ, ユキヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Momozawa, Yukihide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クボ, ミチアキ","creatorNameLang":"ja"},{"creatorName":"クボ, ミチアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kubo, Michiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, ヒデオ","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒデオ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Hideo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"srep_8_1493.pdf","filesize":[{"value":"1.76 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population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005587","relation_version_is_last":true,"title":["A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T00:18:55.856808+00:00"}