{"created":"2024-10-28T07:41:26.992833+00:00","id":2005590,"links":{},"metadata":{"_buckets":{"deposit":"cc39475a-7191-4b4e-8c9f-07af84314f5a"},"_deposit":{"created_by":7,"id":"2005590","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005590"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005590","sets":["1713853213384:1713853295607"]},"author_link":["897"],"control_number":"2005590","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3607","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are indicative of the essential role of RNF213 in the maintenance of CBF.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2018 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Dataset : 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Jun-ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハットリ, ヨリト","creatorNameLang":"ja"},{"creatorName":"ハットリ, ヨリト","creatorNameLang":"ja-Kana"},{"creatorName":"Hattori, Yorito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イグチ, サトシ","creatorNameLang":"ja"},{"creatorName":"イグチ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iguchi, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サイトウ, サトシ","creatorNameLang":"ja"},{"creatorName":"サイトウ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハラダ, コウジ","creatorNameLang":"ja"},{"creatorName":"ハラダ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Kouji H.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オクダ, ヒロコ","creatorNameLang":"ja"},{"creatorName":"オクダ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Okuda, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミネハル, ヨウヘイ","creatorNameLang":"ja"},{"creatorName":"ミネハル, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Mineharu, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"髙木, 康志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Youssefian, Shohab","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イイダ, ヒデヒロ","creatorNameLang":"ja"},{"creatorName":"イイダ, ヒデヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Iida, Hidehiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤモト, ススム","creatorNameLang":"ja"},{"creatorName":"ミヤモト, ススム","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Susumu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イハラ, マサフミ","creatorNameLang":"ja"},{"creatorName":"イハラ, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ihara, Masafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コバヤシ, 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hypoperfusion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dysregulation of RNF213 promotes cerebral hypoperfusion","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005590","relation_version_is_last":true,"title":["Dysregulation of RNF213 promotes cerebral hypoperfusion"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-16T02:46:46.904288+00:00"}