{"created":"2024-10-28T07:41:32.264824+00:00","id":2005591,"links":{},"metadata":{"_buckets":{"deposit":"1abd48ac-7e46-44ae-923b-8046c16602e2"},"_deposit":{"created_by":7,"id":"2005591","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005591"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005591","sets":["1713853213384:1713853295607"]},"author_link":["571","1521"],"control_number":"2005591","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12597","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A population of monocytes, known as Ly6Clo monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6Chi monocytes into Ly6Clo monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Supplementary Information : ncomms_7_12597_s1.pdf\nCorrigendum : https://doi.org/10.1038/ncomms15486"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/ncomms12597"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/ncomms12597","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"320154"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Gamrekelashvili, Jaba","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Giagnorio, Roberto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jussofie, Jasmin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Soehnlein, Oliver","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Duchene, Johan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Briseño, Carlos G.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ramasamy, Saravana K.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Krishnasamy, Kashyap","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Limbourg, Anne","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Häger, Christine","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kapanadze, Tamar","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石舟, 智恵子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hinkel, Rabea","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Radtke, Freddy","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Strobl, Lothar J.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zimber-Strobl, Ursula","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Napp, L. Christian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bauersachs, Johann","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Haller, Hermann","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安友, 康二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kupatt, Christian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murphy, Kenneth M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Adams, Ralf H.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Weber, Christian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Limbourg, Florian P.","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"ncomms_7_12597.pdf","filesize":[{"value":"3.78 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005591/files/ncomms_7_12597.pdf"},"version_id":"80ed05e0-61a6-4dbc-a4ee-023cd7706b2c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-12"}],"displaytype":"detail","filename":"ncomms_7_12597_s1.pdf","filesize":[{"value":"14.2 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005591/files/ncomms_7_12597_s1.pdf"},"version_id":"c820f436-fc39-4866-8ec0-75bf29998d8f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of monocyte cell fate by blood vessels mediated by Notch signalling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of monocyte cell fate by blood vessels mediated by Notch signalling","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-12"},"publish_date":"2018-11-12","publish_status":"0","recid":"2005591","relation_version_is_last":true,"title":["Regulation of monocyte cell fate by blood vessels mediated by Notch signalling"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-16T02:52:17.253726+00:00"}