{"created":"2024-10-28T07:42:35.789985+00:00","id":2005600,"links":{},"metadata":{"_buckets":{"deposit":"9474a110-0e44-4a61-be51-0ebf23f7e0a6"},"_deposit":{"created_by":7,"id":"2005600","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005600"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005600","sets":["1713853213384:1713853295607"]},"author_link":["1524","439","1625"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Effects of testosterone injection","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"441","bibliographicPageStart":"437","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Gynecological Endocrinology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of androgens on gonadotropin-releasing hormone (GnRH) secretion in females have not been fully established. To clarify the direct effects of androgens on hypothalamic reproductive factors, we evaluated the effects of chronic testosterone administration on hypothalamic GnRH regulatory factors in ovariectomized (OVX) female rats. Both testosterone and estradiol reduced the serum luteinizing hormone levels of OVX female rats, indicating that, as has been found for estrogen, testosterone suppresses GnRH secretion via negative feedback. Similarly, the administration of testosterone or estradiol suppressed the hypothalamic mRNA levels of kisspeptin and neurokinin B, both of which are positive regulators of GnRH, whereas it did not affect the hypothalamic mRNA levels of the kisspeptin receptor or neurokinin 3 receptor. On the contrary, the administration of testosterone, but not estradiol, suppressed the hypothalamic mRNA expression of prodynorphin, which is a negative regulator of GnRH. The administration of testosterone did not alter the rats’ serum estradiol levels, indicating that testosterone’s effects on hypothalamic factors might be induced by its androgenic activity. These findings suggest that as well as estrogen, androgens have negative feedback effects on GnRH in females and that the underlying mechanisms responsible for these effects are similar, but do not completely correspond, to the mechanisms underlying the effects of estrogen on GnRH.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09513590","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14730766","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10839977","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 29/11/2017, available online: http://www.tandfonline.com/10.1080/09513590.2017.1409709."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/09513590.2017.1409709"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09513590.2017.1409709","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"339193"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岩佐, 武","creatorNameLang":"ja"},{"creatorName":"イワサ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwasa, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩佐","familyNameLang":"ja"},{"familyName":"イワサ","familyNameLang":"ja-Kana"},{"familyName":"Iwasa","familyNameLang":"en"}],"givenNames":[{"givenName":"武","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207549/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/207549/profile-ja.html"},{"nameIdentifier":"00707903","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00707903"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松崎, 利也","creatorNameLang":"ja"},{"creatorName":"マツザキ, トシヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuzaki, Toshiya","creatorNameLang":"en"}],"familyNames":[{"familyName":"松崎","familyNameLang":"ja"},{"familyName":"マツザキ","familyNameLang":"ja-Kana"},{"familyName":"Matsuzaki","familyNameLang":"en"}],"givenNames":[{"givenName":"利也","givenNameLang":"ja"},{"givenName":"トシヤ","givenNameLang":"ja-Kana"},{"givenName":"Toshiya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1625","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70294692","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70294692"}]},{"creatorNames":[{"creatorName":"矢野, 清人","creatorNameLang":"ja"},{"creatorName":"ヤノ, キヨヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Kiyohito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤナギハラ, リエ","creatorNameLang":"ja"},{"creatorName":"ヤナギハラ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanagihara, Rie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mayila, Yiliyasi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"},{"creatorName":"イラハラ, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Irahara, Minoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"苛原","familyNameLang":"ja"},{"familyName":"イラハラ","familyNameLang":"ja-Kana"},{"familyName":"Irahara","familyNameLang":"en"}],"givenNames":[{"givenName":"稔","givenNameLang":"ja"},{"givenName":"ミノル","givenNameLang":"ja-Kana"},{"givenName":"Minoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1524","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60036/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60036/profile-ja.html"},{"nameIdentifier":"20160070","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20160070"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-29"}],"displaytype":"detail","filename":"gye_34_5_437.pdf","filesize":[{"value":"342 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005600/files/gye_34_5_437.pdf"},"version_id":"4ca50d01-024e-4ea3-ad69-ccd5d0d168b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Testosterone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"kisspeptin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RFRP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NKB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dynorphin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-07"},"publish_date":"2018-11-07","publish_status":"0","recid":"2005600","relation_version_is_last":true,"title":["The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:56:07.984612+00:00"}