{"created":"2024-10-28T07:43:10.078614+00:00","id":2005607,"links":{},"metadata":{"_buckets":{"deposit":"672ba5ca-19c2-4ff4-a8f7-dcc4bdfadfcb"},"_deposit":{"created_by":7,"id":"2005607","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005607"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005607","sets":["1713853213384:1713853295607"]},"author_link":["410","1125","170","1586"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"8-PN promotes recovery from muscle atrophy via Akt pathway","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"R1031","bibliographicPageStart":"R1022","bibliographicVolumeNumber":"311","bibliographic_titles":[{"bibliographic_title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Physiological 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