{"created":"2024-10-28T07:44:58.236951+00:00","id":2005619,"links":{},"metadata":{"_buckets":{"deposit":"48ce8479-57c7-46e7-855c-e23354103e6e"},"_deposit":{"created_by":7,"id":"2005619","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005619"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005619","sets":["1713853213384:1713853295607"]},"author_link":["410","170"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1032","bibliographicPageStart":"1020","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Molecular Nutrition & Food Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Scope: 8-prenyl quercetin (PQ) is a typical prenylflavonoid distributed in plant foods and shows higher potential bioactivity than its parent quercetin (Q) although the mechanisms are not fully understood. This study aims to clarify the anti-inflammatory effects and molecular mechanisms of PQ in cell and animal models, compared to Q.\nMethods and results: RAW264.7 cells were treated with PQ or Q to investigate the influence on the production of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and protein kinases by Western blotting. Nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by the Griess method and ELISA, respectively. Cytokines were assayed by the multiplex technology. Mouse paw edema was induced by lipopolysaccharide (LPS). The results revealed that PQ had stronger inhibition on the productions of iNOS, COX-2, NO, PGE2, and 12 kinds of cytokines, than Q. PQ also showed in vivo anti-inflammatory effect by attenuating mouse paw edema. Molecular data revealed that PQ had no competitive binding to Toll-like receptor 4 (TLR4) with LPS, but directly targeted SEK1-JNK1/2 and MEK1-ERK1/2.\nConclusion: PQ as a potential inhibitor revealed anti-inflammatory effect in both cell and animal models at least by targeting SEK1-JNK1/2 and MEK1-ERK1/2.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16134125","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16134133","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12809751","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11974242","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is the peer reviewed version of the following article: Hisanaga, A. , Mukai, R. , Sakao, K. , Terao, J. and Hou, D. (2016), Anti‐inflammatory effects and molecular mechanisms of 8‐prenyl quercetin. Mol. Nutr. Food Res., 60: 1020-1032, which has been published in final form at https://doi.org/10.1002/mnfr.201500871. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/mnfr.201500871"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/mnfr.201500871","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"319372"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヒサナガ, アユミ","creatorNameLang":"ja"},{"creatorName":"ヒサナガ, アユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisanaga, Ayumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"向井, 理恵","creatorNameLang":"ja"},{"creatorName":"ムカイ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Mukai, Rie","creatorNameLang":"en"}],"familyNames":[{"familyName":"向井","familyNameLang":"ja"},{"familyName":"ムカイ","familyNameLang":"ja-Kana"},{"familyName":"Mukai","familyNameLang":"en"}],"givenNames":[{"givenName":"理恵","givenNameLang":"ja"},{"givenName":"リエ","givenNameLang":"ja-Kana"},{"givenName":"Rie","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"410","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"203812/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/203812/profile-ja.html"},{"nameIdentifier":"90547978","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90547978"}]},{"creatorNames":[{"creatorName":"サカオ, コズエ","creatorNameLang":"ja"},{"creatorName":"サカオ, コズエ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakao, Kozue","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"寺尾, 純二","creatorNameLang":"ja"},{"creatorName":"テラオ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Terao, Junji","creatorNameLang":"en"}],"familyNames":[{"familyName":"寺尾","familyNameLang":"ja"},{"familyName":"テラオ","familyNameLang":"ja-Kana"},{"familyName":"Terao","familyNameLang":"en"}],"givenNames":[{"givenName":"純二","givenNameLang":"ja"},{"givenName":"ジュンジ","givenNameLang":"ja-Kana"},{"givenName":"Junji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10955/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10955/profile-ja.html"},{"nameIdentifier":"60093275","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60093275"}]},{"creatorNames":[{"creatorName":"Hou, De-Xing","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-11-15"}],"displaytype":"detail","filename":"mnfr_60_5_1020.pdf","filesize":[{"value":"3.08 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2005619/files/mnfr_60_5_1020.pdf"},"version_id":"4ee6053d-c643-4985-bef8-5d24e6ffc132"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cellular signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Direct binding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammatory mediators","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular targets","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prenyl quercetin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti‐inflammatory effects and molecular mechanisms of 8‐prenyl quercetin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti‐inflammatory effects and molecular mechanisms of 8‐prenyl quercetin","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-11-15"},"publish_date":"2018-11-15","publish_status":"0","recid":"2005619","relation_version_is_last":true,"title":["Anti‐inflammatory effects and molecular mechanisms of 8‐prenyl quercetin"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T05:16:17.028800+00:00"}