{"created":"2024-10-28T07:47:09.500923+00:00","id":2005652,"links":{},"metadata":{"_buckets":{"deposit":"287c7ad5-ba61-40af-9b3b-7698289996d9"},"_deposit":{"created_by":7,"id":"2005652","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005652"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005652","sets":["1713853213384:1713853295607"]},"author_link":["786","964","1669","713","1647"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"β-Carotene Suppresses Cytokine Production","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"111","bibliographicPageStart":"105","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Cell Biology International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Periodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β-carotene on production of Pg LPS-induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. THP-1 cells were cultured under 5.5 mM or 25 mM glucose conditions, and cells were stimulated with Pg LPS. To investigate the productivity of TNF-α, IL-6 and MCP-1, cell supernatants were collected for ELISA. To examine the effects of NF-kB signals on cytokine production, Bay11-7082 was used. HG enhanced Pg LPS-induced production of TNF-α, IL-6 and MCP-1 via NF-kB signals in THP-1. β-carotene suppressed the enhancement of the Pg LPS-induced cytokine production in THP-1 via NF-κB inactivation. Our results suggest that β-carotene might be a potential anti-inflammatory nutrient for circulating Pg LPS-mediated cytokine production in diabetic patients with periodontitis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Federation for Cell Biology","subitem_publisher_language":"en"},{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10958355","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11544414","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA10882014","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is the peer reviewed version of the following article: Kajiura, Y. , Nishikawa, Y. , Lew, J. H., Kido, J. , Nagata, T. and Naruishi, K. (2018), β‐carotene suppresses Porphyromonas gingivalis lipopolysaccharide‐mediated cytokine production in THP‐1 monocytes cultured with high glucose condition. Cell Biol Int, 42: 105-111, which has been published in final form at https://doi.org/10.1002/cbin.10873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/cbin.10873"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cbin.10873","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"334851"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"梶浦, 由加里","creatorNameLang":"ja"},{"creatorName":"カジウラ, ユカリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kajiura, Yukari","creatorNameLang":"en"}],"familyNames":[{"familyName":"梶浦","familyNameLang":"ja"},{"familyName":"カジウラ","familyNameLang":"ja-Kana"},{"familyName":"Kajiura","familyNameLang":"en"}],"givenNames":[{"givenName":"由加里","givenNameLang":"ja"},{"givenName":"ユカリ","givenNameLang":"ja-Kana"},{"givenName":"Yukari","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"786","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40758869","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40758869"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西川, 泰史","creatorNameLang":"ja"},{"creatorName":"ニシカワ, ヤスフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishikawa, Yasufumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"西川","familyNameLang":"ja"},{"familyName":"ニシカワ","familyNameLang":"ja-Kana"},{"familyName":"Nishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"泰史","givenNameLang":"ja"},{"givenName":"ヤスフミ","givenNameLang":"ja-Kana"},{"givenName":"Yasufumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"964","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"350208/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/350208/profile-ja.html"},{"nameIdentifier":"10823833","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10823833"}]},{"creatorNames":[{"creatorName":"Lew, Jung 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Toshihiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"永田","familyNameLang":"ja"},{"familyName":"ナガタ","familyNameLang":"ja-Kana"},{"familyName":"Nagata","familyNameLang":"en"}],"givenNames":[{"givenName":"俊彦","givenNameLang":"ja"},{"givenName":"トシヒコ","givenNameLang":"ja-Kana"},{"givenName":"Toshihiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1647","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60307/profile-ja.html","nameIdentifierScheme":"徳島大学 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