{"created":"2024-10-28T08:06:35.169207+00:00","id":2005961,"links":{},"metadata":{"_buckets":{"deposit":"528c5150-8448-4aa5-bdba-7c0bad6759d6"},"_deposit":{"created_by":7,"id":"2005961","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005961"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005961","sets":["1713853213384:1713853295607"]},"author_link":["1678","622","1705","1653"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"TGF-β1 and IL-4 induce CCL11 production","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1400","bibliographicPageStart":"1395","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Cell Biology International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transforming growth factor (TGF)-β1 is a multifunctional cytokine, which can control certain functions of various kinds of cells. However, it is unclear whether TGF-β1 affects T-cell migration in periodontal lesions. The aim of this study was to examine the effects of TGF-β1 on the production of C-C chemokine ligand (CCL)11, which is a T-helper 2-type chemokine, in human periodontal ligament cells (HPDLC). Interleukin (IL)-4 induced CCL11 production, but TGF-β1 did not, in HPDLC. However, TGF-β1 enhanced CCL11 production in IL-4-stimulated HPDLC. Western blot analysis showed that the signal transducer and activator of transcription 6 (STAT6) pathway was highly activated in HPDLC that had been stimulated with both IL-4 and TGF-β1. Mitogen-activated protein kinase activation did not differ between the HPDLC treated with a combination of IL-4 and TGF-β1 and those treated with IL-4 or TGF-β1 alone. Moreover, a STAT6 inhibitor significantly inhibited CCL11 production in HPDLC that had been stimulated with IL-4 and TGF-β1. The current study clearly demonstrated that TGF-β1 enhanced IL-4-induced CCL11 production in HPDLC. The STAT6 pathway is important for CCL11 production in IL-4- and TGF-β1-treated HPDLC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Federation for Cell Biology","subitem_publisher_language":"en"},{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 International Federation for Cell Biology","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10656995","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"10958355","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10882014","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11544414","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is the peer reviewed version of the following article: Hosokawa, Y. , Hosokawa, I. , Ozaki, K. and Matsuo, T. (2018), Transforming growth factor‐β1 increases C‐C chemokine ligand 11 production in interleukin 4‐stimulated human periodontal ligament cells. Cell Biol Int, 42: 1395-1400, which has been published in final form at https://doi.org/10.1002/cbin.11030.\nThis article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\n"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/cbin.11030"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/cbin.11030","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"348392"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"細川, 義隆","creatorNameLang":"ja"},{"creatorName":"ホソカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosokawa, 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