{"created":"2024-10-28T08:06:39.664976+00:00","id":2005962,"links":{},"metadata":{"_buckets":{"deposit":"af47fb8e-f159-476b-90ac-790d5fffb538"},"_deposit":{"created_by":7,"id":"2005962","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005962"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005962","sets":["1713853213384:1713853295607"]},"author_link":["1678","622","1705","1653"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Shikonin inhibits inflammatory cytokine production","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1129","bibliographicPageStart":"1124","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Inflammation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has anti-microbial, anti-tumor, and anti-inflammatory effects. The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels of IL-6, IL-8, and CCL20 in HPDLC were determined using an ELISA. Western blot analysis was used to detect nuclear factor kappa B (NF-κB) pathway activation in HPDLC. Shikonin prevented IL-1β- or tumor necrosis factor (TNF)-α-mediated IL-6, IL-8, and CCL20 production in HPDLC. Moreover, we found that shikonin suppressed the phosphorylation and degradation of inhibitor of kappa B-alpha (IκB-α) in IL-1β- or TNF-α-stimulated HPDLC. These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, and CCL20 production in periodontal lesions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03603997","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15732576","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00673765","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12117940","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"松尾","familyNameLang":"ja"},{"familyName":"マツオ","familyNameLang":"ja-Kana"},{"familyName":"Matsuo","familyNameLang":"en"}],"givenNames":[{"givenName":"敬志","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1653","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60313/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60313/profile-ja.html"},{"nameIdentifier":"30173800","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30173800"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-12-13"}],"displaytype":"detail","filename":"inflammation_39_3_1124.pdf","filesize":[{"value":"327 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cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-13"},"publish_date":"2018-12-13","publish_status":"0","recid":"2005962","relation_version_is_last":true,"title":["Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T06:41:50.799261+00:00"}