{"created":"2024-10-28T08:06:44.320321+00:00","id":2005963,"links":{},"metadata":{"_buckets":{"deposit":"c5d67ee2-8ce2-484b-880f-b2554606c638"},"_deposit":{"created_by":7,"id":"2005963","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2005963"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02005963","sets":["1713853213384:1713853295607"]},"author_link":["1678","622","1705","1653"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Melatonin inhibits CXCL10 and MMP-1 production","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1526","bibliographicPageStart":"1520","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Inflammation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC).\nInterleukin (IL)-1β induced CXC chemokine ligand (CXCL)10, matrix metalloproteinase (MMP)-1, and tissue inhibitors of metalloproteinase (TIMP)-1 production in HPDLC. Melatonin decreased CXCL10 and MMP-1 production and increased TIMP-1 production in IL-1β-stimulated HPDLC. Western blot analysis showed that melatonin inhibited p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK) phosphorylation, and IκB-α degradation and phosphorylation in IL-1β-stimulated HPDLC. These results suggest that melatonin might inhibit Th1 cell migration by reducing CXCL10 production. Moreover, melatonin might inhibit soft tissue destruction by decreasing MMP-1 production in periodontal lesions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03603997","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15732576","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00673765","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12117940","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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https://doi.org/10.1007/s10753-016-0386-3"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10753-016-0386-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10753-016-0386-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"314800"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"細川, 育子","creatorNameLang":"ja"},{"creatorName":"ホソカワ, 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Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"松尾","familyNameLang":"ja"},{"familyName":"マツオ","familyNameLang":"ja-Kana"},{"familyName":"Matsuo","familyNameLang":"en"}],"givenNames":[{"givenName":"敬志","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1653","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60313/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60313/profile-ja.html"},{"nameIdentifier":"30173800","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30173800"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-12-13"}],"displaytype":"detail","filename":"inflammation_39_4_1520.pdf","filesize":[{"value":"442 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and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-13"},"publish_date":"2018-12-13","publish_status":"0","recid":"2005963","relation_version_is_last":true,"title":["Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T06:41:49.240199+00:00"}