{"created":"2024-10-28T08:10:48.562095+00:00","id":2006026,"links":{},"metadata":{"_buckets":{"deposit":"eb34a042-6779-4ff4-ba9a-a665f2fc21b7"},"_deposit":{"created_by":7,"id":"2006026","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006026"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006026","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["333","620","394","905","495","398","354","1535"],"control_number":"2006026","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"AGEを介したSmad1とSmad3のリン酸化を介した新規相互作用は糖尿病性腎症の進展を制御する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10548","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Diabetic nephropathy (DN) is the major cause of end-stage renal failure and is associated with increased morbidity and mortality compared with other causes of renal diseases. We previously found that Smad1 plays a critical role in the development of DN both in vitro and in vivo. However, functional interaction between Smad1 and Smad3 signaling in DN is unclear. Here, we addressed the molecular interplay between Smad1 and Smad3 signaling under a diabetic condition by using Smad3-knockout diabetic mice. Extracellular matrix (ECM) protein overexpression and Smad1 activation were observed in the glomeruli of db/db mice but were suppressed in the glomeruli of Smad3+/−; db/db mice. Smad3 activation enhanced the phosphorylation of Smad1 C-terminal domain but decreased the phosphorylation of linker domain, thus regulating Smad1 activation in advanced glycation end product-treated mesangial cells (MCs). However, forced phosphorylation of the Smad1 linker domain did not affect Smad3 activation in MCs. Phosphorylation of the Smad1 linker domain increased in Smad3+/−; db/db mice and probucol-treated db/db mice, which was consistent with the attenuation of ECM overproduction. These results indicate that Smad3 expression and activation or probucol treatment alters Smad1 phosphorylation, thus suggesting new molecular mechanisms underlying DN development and progression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3216号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-09-27"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Hiroyuki Onoの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1384号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-018-28439-1"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-018-28439-1","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"350329"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小野, 広幸","creatorNameLang":"ja"},{"creatorName":"オノ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ono, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安部, 秀斉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"櫻井, 明子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オチ, アリサ","creatorNameLang":"ja"},{"creatorName":"オチ, アリサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ochi, Arisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"冨永, 辰也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田蒔, 昌憲","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岸, 誠司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 太一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長井, 幸二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"コハシ, マサユキ","creatorNameLang":"ja"},{"creatorName":"コハシ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kohashi, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"土井, 俊夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1535","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-12-20"}],"displaytype":"detail","filename":"k3216_abstract_review.pdf","filesize":[{"value":"263 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2006026/files/k3216_abstract_review.pdf"},"version_id":"0e2fbaa3-20fc-462e-a906-70ee6496ece4"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-12-20"}],"displaytype":"detail","filename":"k3216_fulltext.pdf","filesize":[{"value":"2.54 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006026/files/k3216_fulltext.pdf"},"version_id":"290a0c43-267c-467c-84f0-ee6f0d80951b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diabetic nephropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smad1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smad3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-20"},"publish_date":"2018-12-20","publish_status":"0","recid":"2006026","relation_version_is_last":true,"title":["Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-26T02:47:05.103280+00:00"}