{"created":"2024-10-28T08:14:18.841748+00:00","id":2006067,"links":{},"metadata":{"_buckets":{"deposit":"8d4c7e74-a5b0-4d74-a0f1-cba841b884a7"},"_deposit":{"created_by":7,"id":"2006067","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006067"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006067","sets":["1713853213384:1713853295607"]},"author_link":["487","1711","634"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Cepharanthine Inhibits IFN-γ-Induced CXCL10","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"58","bibliographicPageStart":"50","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Inflammation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03603997","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15732576","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00673765","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12117940","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is a post-peer-review, pre-copyedit version of an article published in Inflammation. The final authenticated version is available online at: https://doi.org/10.1007/s10753-017-0662-x"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10753-017-0662-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10753-017-0662-x","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"336704"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"青田, 桂子","creatorNameLang":"ja"},{"creatorName":"アオタ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Aota, Keiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"青田","familyNameLang":"ja"},{"familyName":"アオタ","familyNameLang":"ja-Kana"},{"familyName":"Aota","familyNameLang":"en"}],"givenNames":[{"givenName":"桂子","givenNameLang":"ja"},{"givenName":"ケイコ","givenNameLang":"ja-Kana"},{"givenName":"Keiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"221816/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/221816/profile-ja.html"},{"nameIdentifier":"70437391","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70437391"}]},{"creatorNames":[{"creatorName":"山ノ井, 朋子","creatorNameLang":"ja"},{"creatorName":"ヤマノイ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamanoi, 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Masayuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"東","familyNameLang":"ja"},{"familyName":"アズマ","familyNameLang":"ja-Kana"},{"familyName":"Azuma","familyNameLang":"en"}],"givenNames":[{"givenName":"雅之","givenNameLang":"ja"},{"givenName":"マサユキ","givenNameLang":"ja-Kana"},{"givenName":"Masayuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1711","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60427/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60427/profile-ja.html"},{"nameIdentifier":"20144983","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20144983"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-01-11"}],"displaytype":"detail","filename":"Inflammation_41_1_50.pdf","filesize":[{"value":"674 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006067/files/Inflammation_41_1_50.pdf"},"version_id":"6423be67-837a-4a82-a38b-592dc6cff716"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cepharanthine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CXCL10","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JAK/STAT1 signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary gland ductal cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"primary Sjögren’s syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-01-11"},"publish_date":"2019-01-11","publish_status":"0","recid":"2006067","relation_version_is_last":true,"title":["Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T06:51:31.849029+00:00"}