{"created":"2024-10-28T08:16:51.103034+00:00","id":2006100,"links":{},"metadata":{"_buckets":{"deposit":"9c86770d-1101-439c-a1fb-cb1a85dcee74"},"_deposit":{"created_by":7,"id":"2006100","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006100"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006100","sets":["1713853213384:1713853295607"]},"author_link":["1524","439","1625"],"control_number":"2006100","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"GnIH and Stress-Induced Reproductive Dysfunction","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"62","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Frontiers in Endocrinology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Physical and psychological stressors suppress hypothalamic–pituitary–gonadal axis activity and sexual behavior and consequently induce reproductive dysfunction. Recently, it has been shown that gonadotropin-inhibitory hormone (GnIH), also called RFamide-related peptide 3 (RFRP) in mammals, which is a potent inhibitory regulator of gonadotropin-releasing hormone (GnRH) and gonadotropin, is involved in stress-induced reproductive dysfunction. GnIH/Rfrp (the gene coding RFRP-3) expression and activity are increased by psychological and immune stress, and this alteration suppresses GnRH and gonadotropin secretion. Glucocorticoid acts as a mediator that interacts between stress and hypothalamic GnIH/RFRP-3. GnIH/RFRP-3 also plays important roles in stress-induced suppression of sexual behavior and infertility, and genetic silencing of GnIH/Rfrp completely recovers sexual behavior and fertility. This review summarizes what is currently known about the roles of GnIH in stress-induced reproductive dysfunction.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright © 2017 Iwasa, Matsuzaki, Yano and Irahara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16642392","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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hormone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RFRP-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rfrp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypothalamic–pituitary–gonadal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sexual behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive 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