{"created":"2024-10-28T08:20:55.320651+00:00","id":2006152,"links":{},"metadata":{"_buckets":{"deposit":"01fb502e-72d0-403d-b8e3-f528da910efb"},"_deposit":{"created_by":7,"id":"2006152","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006152"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006152","sets":["1713853213384:1713853295607"]},"author_link":["1687","572","1674","1651","1691","1705","463","629"],"control_number":"2006152","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"746","bibliographicPageStart":"739","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Clinical Oral Investigations","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. The aim of this study is to clarify whether MPC-polymer can suppress the bacterial adherence in oral cavity by a crossover design. We also investigated the number of  Fusobacterium nucleatum, which is the key bacterium forming dental plaque, in clinical samples.\nMaterials and methods This study was a randomized, placebo-controlled, single-blind, crossover study, with two treatment periods separated by a 2-week washout period. We conducted clinical trial with 20 healthy subjects to evaluate the effect of 5% MPC-polymer mouthwash after 5 h on oral microflora. PBS was used as a control. The bacterial number in the gargling sample before and after intervention was counted by an electronic bacterial counter and a culture method. DNA amounts of total bacteria and F. nucleatum were examined by q-PCR.\nResults The numbers of total bacteria and oral streptcocci after 5 h of 5% MPC-polymer treatment significantly decreased, compared to the control group. Moreover, the DNA amounts of total bacteria and F. nucleatum significantly decreased by 5% MPC-polymer mouthwash.\nConclusions We suggest that MPC-polymer coating in the oral cavity may suppress the oral bacterial adherence.\nClinical relevance MPC-polymer can be a potent compound for the control of oral microflora to prevent oral infection.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin Heidelberg","subitem_publisher_language":"en"},{"subitem_publisher":"German Society of Dental, Oral and Craniomandibular Sciences","subitem_publisher_language":"en"},{"subitem_publisher":"European Federation of Conservative Dentistry","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2018 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14326981","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14363771","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11119758","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11619637","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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nucleatum","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind, crossover clinical trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind, crossover clinical trial","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-02-06"},"publish_date":"2019-02-06","publish_status":"0","recid":"2006152","relation_version_is_last":true,"title":["2-Methacryloyloxyethyl 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