| Item type |
文献 / Documents(1) |
| 公開日 |
2019-02-19 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.jphs.2016.02.002 |
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関連名称 |
10.1016/j.jphs.2016.02.002 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats |
| 著者 |
水口, 博之
Das, Asish K.
前山, 一隆
Dev, Shrabanti
Shahriar, Masum
北村, 嘉章
武田, 憲昭
福井, 裕行
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| 抄録 |
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内容記述 |
Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA expression in patients with pollinosis, and its expression level was correlated with that of H1R mRNA. Certain antihistamines, including mepyramine and diphenhydramine, suppress toluene-2,4-diisocyanate (TDI)-induced upregulation of HDC gene expression and increase HDC activity in TDI-sensitized rats. However, d-chlorpheniramine did not demonstrate any effect. The potencies of antihistamine suppressive effects on HDC mRNA elevation were different from their H1R receptor binding affinities. In TDI-sensitized rats, the potencies of antihistamine inhibitory effects on sneezing in the early phase were related to H1R binding. In contrast, the potencies of their inhibitory effects on sneezing in the late phase were correlated with those of suppressive effects on HDC mRNA elevation. Data suggest that in addition to the antihistaminic and inverse agonistic activities, certain antihistamines possess additional properties unrelated to receptor binding and alleviate nasal symptoms in the late phase by inhibiting synthesis and release of histamine by suppressing HDC gene transcription. |
| キーワード |
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主題 |
Allergy |
| キーワード |
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主題 |
Antihistamines |
| キーワード |
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主題 |
Gene expression |
| キーワード |
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主題 |
Histamine signaling |
| キーワード |
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主題 |
Histidine decarboxylase |
| 書誌情報 |
en : Journal of Pharmacological Sciences
巻 130,
号 4,
p. 212-218,
発行日 2016-02-11
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13478613 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12022662 |
| 出版者 |
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出版者 |
Japanese Pharmacological Society |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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権利情報 |
© 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
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識別子 |
311115 |
| 言語 |
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言語 |
eng |
jphs_130_4_212.pdf (675 KB)
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