{"created":"2024-10-28T08:23:52.851409+00:00","id":2006185,"links":{},"metadata":{"_buckets":{"deposit":"0ad93c46-a713-4c99-bdf5-9e8ea640ee0c"},"_deposit":{"created_by":7,"id":"2006185","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006185"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006185","sets":["1713853213384:1713853295607"]},"author_link":["444","572","813"],"control_number":"2006185","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"8239","bibliographicPageStart":"8223","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Head and neck squamous cell carcinoma (HNSCC) has a high capacity for invasion. To identify microRNAs (miRNAs) that regulate HNSCC invasion, we compared miRNA expression profiles between a parent HNSCC cell line and a highly invasive clone. The miR-200 family and miR-203 were downregulated in the clone. Here we focused on the role of miR-203 in invasion and epithelial-mesenchymal transition (EMT) induction in HNSCC. miR-203 was downregulated during EMT induction. Moreover, ectopic overexpression of miR-203 suppressed the invasion and induced mesenchymal-epithelial transition (MET) in HNSCC cells. Interestingly, we identified NUAK family SNF1-like kinase 1 (NUAK1) as a novel target gene of miR-203 by cyclopedic analysis using anti-Ago2 antibody. Increased expression of NUAK1 was observed during EMT induction, and ectopic expression of miR-203 delayed EMT induction by suppressing NUAK1 expression. Moreover, NUAK1 overexpression promoted the invasion of HNSCC cells. Importantly, NUAK1 expression was well correlated with poor differentiation, invasiveness, and lymph node metastasis in HNSCC cases. Overall, miR-203 has a tumor-suppressing role in invasion and EMT induction by targeting NUAK1 in HNSCC, suggesting miR-203 as a potential new diagnostic and therapeutic target for the treatment of HNSCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals, LLC","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19492553","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Issei","creatorNameLang":"en"}],"familyNames":[{"familyName":"井本","familyNameLang":"ja"},{"familyName":"イモト","familyNameLang":"ja-Kana"},{"familyName":"Imoto","familyNameLang":"en"}],"givenNames":[{"givenName":"逸勢","givenNameLang":"ja"},{"givenName":"イッセイ","givenNameLang":"ja-Kana"},{"givenName":"Issei","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30258610","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30258610"}]},{"creatorNames":[{"creatorName":"アビコ, ヨシミツ","creatorNameLang":"ja"},{"creatorName":"アビコ, ヨシミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Abiko, Yoshimitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Xu, Dan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクナガ, サオリ","creatorNameLang":"ja"},{"creatorName":"フクナガ, サオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukunaga, Saori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タハラ, ヒデトシ","creatorNameLang":"ja"},{"creatorName":"タハラ, ヒデトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tahara, Hidetoshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"工藤, 保誠","creatorNameLang":"ja"},{"creatorName":"クドウ, ヤスセイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kudo, 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タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, Takashi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-03-05"}],"displaytype":"detail","filename":"onc_7_7_8223.pdf","filesize":[{"value":"4.68 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006185/files/onc_7_7_8223.pdf"},"version_id":"8f33c65f-793f-444e-b72f-d2e3461b0be3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA (miRNA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial-mesenchymal transition (EMT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"head and neck squamous cell carcinoma (HNSCC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microarray","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-05"},"publish_date":"2019-03-05","publish_status":"0","recid":"2006185","relation_version_is_last":true,"title":["microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T06:07:49.843463+00:00"}