{"created":"2024-10-28T08:24:03.929162+00:00","id":2006187,"links":{},"metadata":{"_buckets":{"deposit":"0a20a0a2-8f85-41fb-8852-6c78a9006193"},"_deposit":{"created_by":7,"id":"2006187","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006187"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006187","sets":["1713853213384:1713853295607"]},"author_link":["852"],"control_number":"2006187","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"25","bibliographicPageEnd":"38597","bibliographicPageStart":"38586","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Complete remission by induction therapy in acute myelogenous leukemia (AML) can be achieved due to improvements in supportive and optimized therapy. However, more than 20% of patients will still need to undergo salvage therapy, and most will have a poor prognosis. Determining the specificity of drugs to leukemia cells is important since this will maximize the dose of chemotherapeutic agents that can be administered to AML patients. In turn, this would be expected to lead to reduced drug toxicity and its increased efficacy. We targeted Notch-1 positive AML cells utilizing fucose-bound liposomes, since activation of Notch-1 is required for O-fucosylation. Herein, we report that intravenously injected, L-fucose-bound liposomes containing daunorubicin can be successfully delivered to AML cells that express fucosylated antigens. This resulted in efficient tumor growth inhibition in tumor-bearing mice and decreased proliferation of AML patient-derived leukemia cells. Thus, biological targeting by fucose-bound liposomes that takes advantage of the intrinsic characteristics of AML cells could be a promising new strategy for Notch-1 positive-AML treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals, LLC","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19492553","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.18632/oncotarget.9558"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18632/oncotarget.9558","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"332781"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オノ, ミチヒロ","creatorNameLang":"ja"},{"creatorName":"オノ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ono, Michihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タキモト, リシュウ","creatorNameLang":"ja"},{"creatorName":"タキモト, リシュウ","creatorNameLang":"ja-Kana"},{"creatorName":"Takimoto, Rishu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオスガ, タカヒロ","creatorNameLang":"ja"},{"creatorName":"オオスガ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Osuga, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカガワ, ユタカ","creatorNameLang":"ja"},{"creatorName":"オカガワ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Okagawa, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラカワ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"ヒラカワ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirakawa, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシダ, マコト","creatorNameLang":"ja"},{"creatorName":"ヨシダ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アリハラ, ヨウヘイ","creatorNameLang":"ja"},{"creatorName":"アリハラ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Arihara, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウエムラ, ナオキ","creatorNameLang":"ja"},{"creatorName":"ウエムラ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uemura, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤサカ, ナオキ","creatorNameLang":"ja"},{"creatorName":"ハヤサカ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayasaka, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, ショウゴ","creatorNameLang":"ja"},{"creatorName":"ミウラ, ショウゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Shogo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツノ, テッペイ","creatorNameLang":"ja"},{"creatorName":"マツノ, テッペイ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuno, Teppei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タムラ, フミト","creatorNameLang":"ja"},{"creatorName":"タムラ, フミト","creatorNameLang":"ja-Kana"},{"creatorName":"Tamura, Fumito","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"康史","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321662/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/321662/profile-ja.html"}]},{"creatorNames":[{"creatorName":"サトウ, ツトム","creatorNameLang":"ja"},{"creatorName":"サトウ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Tsutomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イヤマ, サトシ","creatorNameLang":"ja"},{"creatorName":"イヤマ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iyama, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja"},{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyanishi, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカダ, コウイチ","creatorNameLang":"ja"},{"creatorName":"タカダ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Takada, Kohichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja"},{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobune, Masayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja"},{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Junji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-03-05"}],"displaytype":"detail","filename":"onc_7_25_38586.pdf","filesize":[{"value":"4.14 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006187/files/onc_7_25_38586.pdf"},"version_id":"12b3c178-9317-48b4-896f-b7f928424f17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AML","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Notch-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"targeting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liposome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"L-fucose","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-05"},"publish_date":"2019-03-05","publish_status":"0","recid":"2006187","relation_version_is_last":true,"title":["Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:22:21.617448+00:00"}