{"created":"2024-10-28T08:24:08.381974+00:00","id":2006188,"links":{},"metadata":{"_buckets":{"deposit":"71bb22ba-a0c3-46dc-8ad4-7db6908ac442"},"_deposit":{"created_by":7,"id":"2006188","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006188"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006188","sets":["1713853213384:1713853295607"]},"author_link":["852"],"control_number":"2006188","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"39","bibliographicPageEnd":"64341","bibliographicPageStart":"64330","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells have increased intracellular iron levels as compared with normal cells. In experiments to test the effect of iron chelation on the growth of MM cells, we found that deferasirox (DFX), an oral iron chelator used to treat iron overload in clinical practice, inhibits MM cell growth both in vivo and in vitro. Mechanistically, DFX was found to induce apoptosis of MM cells via the inhibition of proline-rich tyrosine kinase 2 (Pyk2), which is known to promote tumor growth in MM. Inhibition of Pyk2 is caused by the suppression of reactive oxygen species, and leads to downregulation of the Wnt/β-catenin signaling pathway. Taken together, our findings indicate that high levels of intracellular iron, which might be due to low ferroportin expression, play a role in MM pathophysiology. Therefore, DFX may provide a therapeutic option for MM that is driven by deregulated iron homeostasis and/or Pyk2/Wnt signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals, LLC","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19492553","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.18632/oncotarget.11830"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18632/oncotarget.11830","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"332773"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"カミハラ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"カミハラ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamihara, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカダ, コウイチ","creatorNameLang":"ja"},{"creatorName":"タカダ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Takada, Kohichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, ツトム","creatorNameLang":"ja"},{"creatorName":"サトウ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Tsutomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワノ, ユタカ","creatorNameLang":"ja"},{"creatorName":"カワノ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムラセ, カズユキ","creatorNameLang":"ja"},{"creatorName":"ムラセ, カズユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Murase, Kazuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アリハラ, ヨウヘイ","creatorNameLang":"ja"},{"creatorName":"アリハラ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Arihara, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キクチ, ショウヘイ","creatorNameLang":"ja"},{"creatorName":"キクチ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kikuchi, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤサカ, ナオタカ","creatorNameLang":"ja"},{"creatorName":"ハヤサカ, ナオタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayasaka, Naotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウサミ, マコト","creatorNameLang":"ja"},{"creatorName":"ウサミ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Usami, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イヤマ, サトシ","creatorNameLang":"ja"},{"creatorName":"イヤマ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iyama, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja"},{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyanishi, Koji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"康史","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321662/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/321662/profile-ja.html"}]},{"creatorNames":[{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja"},{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobune, Masayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja"},{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Junji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-03-05"}],"displaytype":"detail","filename":"onc_7_39_64330.pdf","filesize":[{"value":"5.79 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006188/files/onc_7_39_64330.pdf"},"version_id":"682aa970-0b01-47b5-b2d0-4b4f04a5c538"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"deferasirox","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pyk2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple myeloma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-05"},"publish_date":"2019-03-05","publish_status":"0","recid":"2006188","relation_version_is_last":true,"title":["The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:22:21.373068+00:00"}