{"created":"2024-10-28T08:24:16.969761+00:00","id":2006190,"links":{},"metadata":{"_buckets":{"deposit":"b9a8c1f9-eaae-4af0-b290-e364ca6ebe21"},"_deposit":{"created_by":7,"id":"2006190","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006190"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006190","sets":["1713853213384:1713853295607"]},"author_link":["316"],"control_number":"2006190","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"26128","bibliographicPageStart":"26122","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The purpose of this study was to test whether immunohistochemical (IHC) Ki67 levels after short-term preoperative hormone therapy (post-Ki67) predict similar numbers of patients with favorable prognoses as genomic markers.\nResults: Thirty paired cases (60 samples) were enrolled in this study. Post-Ki67 levels were significantly lower than pre-treatment Ki67 levels (P < 0.001). Post-Ki67 predicted more low-risk cases (83.3%, 25/30) than pre-genomic surrogate signature(GSS) (66.7%: 20/30), but the difference in predictive power was not significant (P = 0.233). Proliferation (MKI67, STK15, Survivin, CCNB1, and MYBL2) and estrogen (ER, PGR, BCL2, and SCUBE2) related signatures were significantly downregulated after therapy (P < 0.001 and 0.041, respectively).\nMaterials and Methods: Core needle biopsy specimens of primary breast cancer were collected at Okayama University Hospital from hormone receptor-positive and human epidermal growth factor 2-negative patients that subsequently received two weeks of neoadjuvant hormone therapy. Paired post-treatment specimens from surgical samples were also collected. IHC Ki67 levels and GSS were compared between pre- and post-hormone treatment samples. Changes of gene expression pattern in short-term hormone therapy were also assessed.\nConclusions: IHC based post-Ki67 levels may have distinct predictive power compared with the naïve IHC Ki67. Future studies with larger cohorts and longer follow-up periods may be needed to validate our results.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals, LLC","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright: Iwamoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19492553","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.18632/oncotarget.15385"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18632/oncotarget.15385","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"324026"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イワモト, タカユキ","creatorNameLang":"ja"},{"creatorName":"イワモト, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwamoto, Takayuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"片桐, 豊雅","creatorNameLang":"ja"},{"creatorName":"カタギリ, トヨマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Katagiri, Toyomasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"片桐","familyNameLang":"ja"},{"familyName":"カタギリ","familyNameLang":"ja-Kana"},{"familyName":"Katagiri","familyNameLang":"en"}],"givenNames":[{"givenName":"豊雅","givenNameLang":"ja"},{"givenName":"トヨマサ","givenNameLang":"ja-Kana"},{"givenName":"Toyomasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"316","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174774/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174774/profile-ja.html"},{"nameIdentifier":"60291895","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60291895"}]},{"creatorNames":[{"creatorName":"ニイクラ, ナオキ","creatorNameLang":"ja"},{"creatorName":"ニイクラ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Niikura, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヨシ, ユウイチロウ","creatorNameLang":"ja"},{"creatorName":"ミヨシ, ユウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyoshi, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コウチ, マリコ","creatorNameLang":"ja"},{"creatorName":"コウチ, マリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kochi, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノガミ, トモヒロ","creatorNameLang":"ja"},{"creatorName":"ノガミ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nogami, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シエン, タダヒコ","creatorNameLang":"ja"},{"creatorName":"シエン, タダヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Shien, Tadahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モトキ, タカユキ","creatorNameLang":"ja"},{"creatorName":"モトキ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Motoki, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タイラ, ナルト","creatorNameLang":"ja"},{"creatorName":"タイラ, ナルト","creatorNameLang":"ja-Kana"},{"creatorName":"Taira, Naruto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオモリ, マサコ","creatorNameLang":"ja"},{"creatorName":"オオモリ, マサコ","creatorNameLang":"ja-Kana"},{"creatorName":"Omori, Masako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トクダ, ユタカ","creatorNameLang":"ja"},{"creatorName":"トクダ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Tokuda, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジワラ, トシヨシ","creatorNameLang":"ja"},{"creatorName":"フジワラ, トシヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujiwara, Toshiyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ドイハラ, ヒロヨシ","creatorNameLang":"ja"},{"creatorName":"ドイハラ, ヒロヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Doihara, Hiroyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gyorffy, Balazs","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツオカ, ジュンジ","creatorNameLang":"ja"},{"creatorName":"マツオカ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuoka, Junji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-03-05"}],"displaytype":"detail","filename":"onc_8_16_26122.pdf","filesize":[{"value":"762 KB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006190/files/onc_8_16_26122.pdf"},"version_id":"3a08d685-ff02-4eaf-87e9-d71fa6ecc554"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"short-term hormone therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IHC Ki67","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"genomic marker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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