{"created":"2024-10-29T00:22:46.000669+00:00","id":2006340,"links":{},"metadata":{"_buckets":{"deposit":"7863dc30-79c7-4632-a4a5-d13fe9f2abd0"},"_deposit":{"created_by":7,"id":"2006340","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006340"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006340","sets":["1713853213384:1713853296295:1716267876683:1716268552315"]},"author_link":["1624","708","1625","1629","1524"],"control_number":"2006340","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"サイトカイン誘発好中球化学誘引物質の発現はTNFα発現を抑制することにより卵胞の閉鎖およびアポトーシスから回避させる","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"165","bibliographicPageStart":"157","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Reproductive Medicine and Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: Cytokine-induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin-8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined.\nMethods: Whether antibody-blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration was investigated. The effect of the antibody on the level of inflammatory cytokine production and follicular atresia was examined. Apoptosis was measured by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and via analysis of the messenger RNA expression of Bcl-2 and Bcl2-associated X (Bax).\nResults: The anti-CINC/gro antibody treatment decreased the number of ovulated oocytes. The messenger RNA levels of cyclooxygenase-2 and interleukin-1 beta were decreased by the antibody treatment, whereas that of tumor necrosis factor (TNF) alpha was increased. The TUNEL analysis revealed a larger number of apoptotic cells in the antibody group, compared with those in the control group, as well as a significant increase in the Bax/Bcl-2 ratio 24 hours after human chorionic gonadotropin administration.\nConclusion: These findings suggest that ovulation is accelerated by neutrophil infiltration into the theca layer. The CINC/gro appears to synergize with interleukin-1 beta for ovulation. By contrast, the data suggest that CINC/gro expression suppresses TNF alpha expression and that CINC/gro expression therefore prevents the follicles from undergoing atresia and apoptosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"},{"subitem_publisher":"Japan Society for Reproductive Medicine","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.© 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14470578","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11706516","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2107号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-19"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Yu Tanakaの学位論文として提出され, 学位審査・授与の対象となっている。"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"乙医第1756号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1002/rmb2.12022"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/rmb2.12022","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"339190"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 優","creatorNameLang":"ja"},{"creatorName":"タナカ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Yu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"桑原, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウシゴエ, ケンジロウ","creatorNameLang":"ja"},{"creatorName":"ウシゴエ, ケンジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ushigoe, Kenjiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja"},{"creatorName":"ヤノ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yano, Yuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タニグチ, ユカ","creatorNameLang":"ja"},{"creatorName":"タニグチ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 由理","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松崎, 利也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安井, 敏之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1524","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-04-03"}],"displaytype":"detail","filename":"o2107_abstract_review.pdf","filesize":[{"value":"227 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2006340/files/o2107_abstract_review.pdf"},"version_id":"9cddad39-8d4c-4421-906f-44c993fc9db3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-04-03"}],"displaytype":"detail","filename":"o2107_fulltext.pdf","filesize":[{"value":"755 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006340/files/o2107_fulltext.pdf"},"version_id":"0989e34b-ae4c-421d-8ee9-a2cfa051bbb4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"follicle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ovary","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ovulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor alpha","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of cytokine-induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of cytokine-induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268552315"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-04-03"},"publish_date":"2019-04-03","publish_status":"0","recid":"2006340","relation_version_is_last":true,"title":["Expression of cytokine-induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-27T02:15:48.424182+00:00"}