{"created":"2024-10-29T00:31:13.953013+00:00","id":2006437,"links":{},"metadata":{"_buckets":{"deposit":"11a47e13-d1ef-484b-81d4-a35efe7739e2"},"_deposit":{"created_by":7,"id":"2006437","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006437"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006437","sets":["1713829974766:1713854681789:1716364514295:1716365279946","1713853213384:1713853295607"]},"author_link":["870","274","435","1631","190","430"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"NADPH oxidase and ROS in kidney growth","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"98","bibliographicPageStart":"93","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ureteric bud branching and nephrogenesis are performed through large-scale proliferation and apoptosis events during renal development. Reactive oxygen species (ROS), produced by NADPH oxidase, may contribute to cell behaviors, including proliferation and apoptosis. We investigated the role of NADPH oxidase expression and ROS production in developing kidneys. Immunohistochemistry revealed that NADPH oxidase components were expressed on epithelial cells in ureteric bud branches, as well as on immature glomerular cells and epithelial cells in nephrogenic zones. ROS production, detected by dihydroethidium assay, was strongly observed in ureteric bud branches and nephrogenic zones, corresponding with NADPH oxidase localization. Organ culture of E14 kidneys revealed that the inhibition of NADPH oxidase significantly reduced the number of ureteric bud branches and tips, consistent with reduced ROS production. This was associated with reduced expression of phosphorylated ERK1/2 and increased expression of cleaved caspase-3. Organ culture of E18 kidneys showed that the inhibition of NADPH oxidase reduced nephrogenic zone size, accompanied by reduced ROS production, fewer proliferating cell nuclear antigen-positive cells, lower p-ERK1/2 expression, and increased expression of cleaved caspase-3. These results demonstrate that ROS produced by NADPH oxidase might play an important role in ureteric bud branching and nephrogenesis by regulating proliferation and apoptosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.66.93"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.66.93","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"370175"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近藤, 秀治","creatorNameLang":"ja"},{"creatorName":"コンドウ, シュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Shuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"近藤","familyNameLang":"ja"},{"familyName":"コンドウ","familyNameLang":"ja-Kana"},{"familyName":"Kondo","familyNameLang":"en"}],"givenNames":[{"givenName":"秀治","givenNameLang":"ja"},{"givenName":"シュウジ","givenNameLang":"ja-Kana"},{"givenName":"Shuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"274","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00380080","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00380080"}]},{"creatorNames":[{"creatorName":"マツウラ, サト","creatorNameLang":"ja"},{"creatorName":"マツウラ, サト","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuura, Sato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ariunbold, Jamba","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"木下, ゆき子","creatorNameLang":"ja"},{"creatorName":"キノシタ, ユキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kinoshita, Yukiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"木下","familyNameLang":"ja"},{"familyName":"キノシタ","familyNameLang":"ja-Kana"},{"familyName":"Kinoshita","familyNameLang":"en"}],"givenNames":[{"givenName":"ゆき子","givenNameLang":"ja"},{"givenName":"ユキコ","givenNameLang":"ja-Kana"},{"givenName":"Yukiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70597806","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70597806"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"漆原, 真樹","creatorNameLang":"ja"},{"creatorName":"ウルシハラ, マキ","creatorNameLang":"ja-Kana"},{"creatorName":"Urushihara, Maki","creatorNameLang":"en"}],"familyNames":[{"familyName":"漆原","familyNameLang":"ja"},{"familyName":"ウルシハラ","familyNameLang":"ja-Kana"},{"familyName":"Urushihara","familyNameLang":"en"}],"givenNames":[{"givenName":"真樹","givenNameLang":"ja"},{"givenName":"マキ","givenNameLang":"ja-Kana"},{"givenName":"Maki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"190","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121546/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121546/profile-ja.html"},{"nameIdentifier":"50403689","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50403689"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"須賀, 健一","creatorNameLang":"ja"},{"creatorName":"スガ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Suga, Ken-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"須賀","familyNameLang":"ja"},{"familyName":"スガ","familyNameLang":"ja-Kana"},{"familyName":"Suga","familyNameLang":"en"}],"givenNames":[{"givenName":"健一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Ken-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207538/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/207538/profile-ja.html"},{"nameIdentifier":"70511335","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70511335"}]},{"creatorNames":[{"creatorName":"オザキ, ナツコ","creatorNameLang":"ja"},{"creatorName":"オザキ, ナツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Natsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"永井, 隆","creatorNameLang":"ja"},{"creatorName":"ナガイ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagai, Takashi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤岡, 啓介","creatorNameLang":"ja"},{"creatorName":"フジオカ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujioka, Keisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤岡","familyNameLang":"ja"},{"familyName":"フジオカ","familyNameLang":"ja-Kana"},{"familyName":"Fujioka","familyNameLang":"en"}],"givenNames":[{"givenName":"啓介","givenNameLang":"ja"},{"givenName":"ケイスケ","givenNameLang":"ja-Kana"},{"givenName":"Keisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"870","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323771/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/323771/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"香美, 祥二","creatorNameLang":"ja"},{"creatorName":"カガミ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagami, Shoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"香美","familyNameLang":"ja"},{"familyName":"カガミ","familyNameLang":"ja-Kana"},{"familyName":"Kagami","familyNameLang":"en"}],"givenNames":[{"givenName":"祥二","givenNameLang":"ja"},{"givenName":"ショウジ","givenNameLang":"ja-Kana"},{"givenName":"Shoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1631","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60248/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60248/profile-ja.html"},{"nameIdentifier":"00224337","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00224337"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-07-04"}],"displaytype":"detail","filename":"jmi_66_1-2_93.pdf","filesize":[{"value":"1.15 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006437/files/jmi_66_1-2_93.pdf"},"version_id":"d953b298-1046-47e3-945d-5eba608ec2b9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"developing kidney","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NADPH oxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of NADPH oxidase and production of reactive oxygen species contribute to ureteric bud branching and nephrogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of NADPH oxidase and production of reactive oxygen species contribute to ureteric bud branching and nephrogenesis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365279946"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-04"},"publish_date":"2019-07-04","publish_status":"0","recid":"2006437","relation_version_is_last":true,"title":["Expression of NADPH oxidase and production of reactive oxygen species contribute to ureteric bud branching and nephrogenesis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:44:59.152591+00:00"}