{"created":"2024-10-29T00:31:52.140552+00:00","id":2006445,"links":{},"metadata":{"_buckets":{"deposit":"824da60d-b788-49bf-bc92-735c347d970a"},"_deposit":{"created_by":7,"id":"2006445","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006445"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006445","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["310","756","189","813","1548"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"177","bibliographicPageStart":"170","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Metabolic Syndrome and Related Disorders","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.\nMethods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.\nResults: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.\nConclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert, Inc.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017, Mary Ann Liebert, Inc.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15404196","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15578518","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11853678","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12814809","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3265号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-19"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Syunsuke Watanabeの学位論文として提出され，学位審査・授与の対象となっている。\nFinal publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/met.2016.0114\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1414号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1089/met.2016.0114"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1089/met.2016.0114","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"325411"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 俊介","creatorNameLang":"ja"},{"creatorName":"ワタナベ, シュンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, 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