{"created":"2024-10-29T00:33:40.948681+00:00","id":2006465,"links":{},"metadata":{"_buckets":{"deposit":"a1bacd24-0663-4f7a-a173-2ddaa4055388"},"_deposit":{"created_by":7,"id":"2006465","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006465"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006465","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["954","1683","784","243","813","572","1721"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Effect of CNT exposure on alveolar macrophages","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"e0205702","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nNanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.\nMethods and finding\nIn this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.\nConclusions\nThese results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 Otsuka et al.\nThis is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3281号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kunihiro Otsukaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第446号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1371/journal.pone.0205702"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0205702","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"349397"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大塚, 邦紘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヤマダ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ヤマダ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, ユウジ","creatorNameLang":"ja"},{"creatorName":"タカハシ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Taquahashi, Yuhji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"新垣, 理恵子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"牛尾, 綾","creatorNameLang":"ja"},{"creatorName":"ウシオ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ushio, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"齋藤, 雅子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 安希子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"工藤, 保誠","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カンノ, ジュン","creatorNameLang":"ja"},{"creatorName":"カンノ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Kanno, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石丸, 直澄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1721","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-13"}],"displaytype":"detail","filename":"k3281_abstract.pdf","filesize":[{"value":"102 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2006465/files/k3281_abstract.pdf"},"version_id":"605e132a-b020-4d8f-ba3e-bca8e035a818"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-13"}],"displaytype":"detail","filename":"k3281_review.pdf","filesize":[{"value":"38 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2006465/files/k3281_review.pdf"},"version_id":"e528e15a-96a3-410d-93e9-ae80cf03303b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-13"}],"displaytype":"detail","filename":"k3281_fulltext.pdf","filesize":[{"value":"2.72 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006465/files/k3281_fulltext.pdf"},"version_id":"88f74d24-4d79-4ae8-b357-cedd1b3299c4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carbon nanotube","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Taquann methods","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alveolar macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-06-13"},"publish_date":"2019-06-13","publish_status":"0","recid":"2006465","relation_version_is_last":true,"title":["Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-29T00:33:53.756994+00:00"}