{"created":"2024-10-29T00:42:42.749073+00:00","id":2006578,"links":{},"metadata":{"_buckets":{"deposit":"7f877407-49ab-4026-826f-473ddc69f0c0"},"_deposit":{"created_by":7,"id":"2006578","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006578"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006578","sets":["1713853213384:1713853295607"]},"author_link":["1251","323"],"control_number":"2006578","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Potential Role of Rebamipide in Osteoclast Differentiation","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"62","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Current Rheumatology Reviews","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that involves changes in subchondral bone and progressive degradation of cartilage. Currently, rebamipide, a gastroprotective drug, is administered to protect gastric mucosa and accelerate ulcer healing.\nObjectives: Recent studies have shown that rebamipide also attenuates cartilage degeneration by suppressing oxidative damage and inducing homeostasis of the extracellular matrix of articular chondrocytes. Regarding the latter, reduced expression of cathepsin K, NFATc1, c-Src, and integrin β3, and increased expression of nuclear factor-kappa B, have been found to be mediated by the transcription factor, receptor activator of nuclear factor kappa-B ligand (RANKL).\nMethods: Treatment with rebamipide was also found to activate, mitogen-activated protein kinases such as p38, ERK, and JNK to reduce osteoclast differentiation. Taken together, these results strongly indicate that rebamipide mediates inhibitory effects on cartilage degradation and osteoclastogenesis in TMJ-OA.\nResults and Conclusion: Here, we highlight recent evidence regarding the potential for rebamipide to affect osteoclast differentiation and TMJ-OA pathogenesis. We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Bentham Science","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15733971","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18756360","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12061959","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2174/1573397113666171017113441"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2174/1573397113666171017113441","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"334344"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"井澤, 俊","creatorNameLang":"ja"},{"creatorName":"イザワ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"井澤","familyNameLang":"ja"},{"familyName":"イザワ","familyNameLang":"ja-Kana"},{"familyName":"Izawa","familyNameLang":"en"}],"givenNames":[{"givenName":"俊","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1251","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30380017","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30380017"}]},{"creatorNames":[{"creatorName":"フタミ, イスラミ ラフマ","creatorNameLang":"ja"},{"creatorName":"フタミ, イスラミ ラフマ","creatorNameLang":"ja-Kana"},{"creatorName":"Hutami, Islamy Rahma","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"},{"creatorName":"タナカ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"栄二","givenNameLang":"ja"},{"givenName":"エイジ","givenNameLang":"ja-Kana"},{"givenName":"Eiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174876/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174876/profile-ja.html"},{"nameIdentifier":"40273693","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40273693"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-08-09"}],"displaytype":"detail","filename":"crr_14_1_62.pdf","filesize":[{"value":"3.38 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006578/files/crr_14_1_62.pdf"},"version_id":"dcb8086d-8665-4e6c-9fc0-c32355495738"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Rebamipide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclast differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chondrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TMJ-OA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mitogen-activated","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-09"},"publish_date":"2019-08-09","publish_status":"0","recid":"2006578","relation_version_is_last":true,"title":["Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T07:41:37.566839+00:00"}