{"created":"2024-10-29T00:57:27.250642+00:00","id":2006763,"links":{},"metadata":{"_buckets":{"deposit":"6b99cc6c-828c-4d2a-8d2c-d2ec684ba299"},"_deposit":{"created_by":7,"id":"2006763","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006763"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006763","sets":["1713853213384:1713853295607"]},"author_link":["386","521","1567","495","1418","168","514","482","228"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Inhibitory action of iron on erythropoietin","subitem_alternative_title_language":"en"},{"subitem_alternative_title":"Inhibitory action of iron on erythropoietin via oxidative stress-HIF-2α pathway","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"566","bibliographicPageStart":"555","bibliographicVolumeNumber":"97","bibliographic_titles":[{"bibliographic_title":"Laboratory Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Renal anemia is a major complication in chronic kidney disease (CKD). Iron supplementation, as well as erythropoiesis-stimulating agents, are widely used for treatment of renal anemia. However, excess iron causes oxidative stress via the Fenton reaction, and iron supplementation might damage remnant renal function including erythropoietin (EPO) production in CKD. EPO gene expression was suppressed in mice following direct iron treatment. Hypoxia-inducible factor-2 alpha (HIF-2α), a positive regulator of the EPO gene, was also diminished in the kidney of mice following iron treatment. Anemia-induced increase in EPO and HIF-2α expression was also inhibited by iron-treatment. In in vitro experiments using EPO-producing HepG2 cells, iron stimulation reduced the expression of the EPO gene, as well as HIF-2α. Moreover, iron treatment augmented oxidative stress, and iron-induced reduction of EPO and HIF-2α expression was restored by tempol, an anti-oxidant compound. HIF-2α interaction with the EPO promoter was inhibited by iron treatment, and was restored by tempol. These findings suggested that iron supplementation reduced EPO gene expression via an oxidative stress-HIF-2α-dependent signaling pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15300307","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"00236837","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12189985","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00713961","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is the Author's Accepted Manuscript of the following article: Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation, Keisuke Oshima, Yasumasa Ikeda, Yuya Horinouchi, Hiroaki Watanabe, Hirofumi Hamano, Yoshitaka Kihira, Seiji Kishi, Yuki Izawa-Ishizawa, Licht Miyamoto, Tasuku Hirayama, Hideko Nagasawa, Keisuke Ishizawa, Koichiro Tsuchiya & Toshiaki Tamaki, Laboratory Investigation 97, 555–566 (2017), which has been published in final form at https://doi.org/10.1038/labinvest.2017.11."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/labinvest.2017.11"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/labinvest.2017.11","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"322994"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オオシマ, ケイスケ","creatorNameLang":"ja"},{"creatorName":"オオシマ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Oshima, Keisuke","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219499/profile-ja.html"},{"nameIdentifier":"60432754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60432754"}]},{"creatorNames":[{"creatorName":"堀ノ内, 裕也","creatorNameLang":"ja"},{"creatorName":"ホリノウチ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Horinouchi, Yuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Hiroaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱野, 裕章","creatorNameLang":"ja"},{"creatorName":"ハマノ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamano, Hirofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱野","familyNameLang":"ja"},{"familyName":"ハマノ","familyNameLang":"ja-Kana"},{"familyName":"Hamano","familyNameLang":"en"}],"givenNames":[{"givenName":"裕章","givenNameLang":"ja"},{"givenName":"ヒロフミ","givenNameLang":"ja-Kana"},{"givenName":"Hirofumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1418","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"373198/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/373198/profile-ja.html"},{"nameIdentifier":"10847289","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10847289"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"木平, 孝高","creatorNameLang":"ja"},{"creatorName":"キヒラ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kihira, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"木平","familyNameLang":"ja"},{"familyName":"キヒラ","familyNameLang":"ja-Kana"},{"familyName":"Kihira","familyNameLang":"en"}],"givenNames":[{"givenName":"孝高","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"386","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90377276","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90377276"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岸, 誠司","creatorNameLang":"ja"},{"creatorName":"キシ, セイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishi, Seiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"岸","familyNameLang":"ja"},{"familyName":"キシ","familyNameLang":"ja-Kana"},{"familyName":"Kishi","familyNameLang":"en"}],"givenNames":[{"givenName":"誠司","givenNameLang":"ja"},{"givenName":"セイジ","givenNameLang":"ja-Kana"},{"givenName":"Seiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"495","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10519507","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10519507"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(井澤)石澤, 有紀","creatorNameLang":"ja"},{"creatorName":"(イザワ)イシザワ, ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa-Ishizawa, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"(井澤)石澤","familyNameLang":"ja"},{"familyName":"(イザワ)イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Izawa-Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"有紀","givenNameLang":"ja"},{"givenName":"ユキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"521","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229223/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229223/profile-ja.html"},{"nameIdentifier":"40610192","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40610192"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 理人","creatorNameLang":"ja"},{"creatorName":"ミヤモト, リヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Licht","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"理人","givenNameLang":"ja"},{"givenName":"リヒト","givenNameLang":"ja-Kana"},{"givenName":"Licht","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"514","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60456887","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60456887"}]},{"creatorNames":[{"creatorName":"ヒラヤマ, タスク","creatorNameLang":"ja"},{"creatorName":"ヒラヤマ, タスク","creatorNameLang":"ja-Kana"},{"creatorName":"Hirayama, Tasuku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"永澤, 秀子","creatorNameLang":"ja"},{"creatorName":"ナガサワ, ヒデコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagasawa, Hideko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石澤, 啓介","creatorNameLang":"ja"},{"creatorName":"イシザワ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizawa, Keisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"石澤","familyNameLang":"ja"},{"familyName":"イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"啓介","givenNameLang":"ja"},{"givenName":"ケイスケ","givenNameLang":"ja-Kana"},{"givenName":"Keisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"228","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"141809/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/141809/profile-ja.html"},{"nameIdentifier":"60398013","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60398013"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土屋, 浩一郎","creatorNameLang":"ja"},{"creatorName":"ツチヤ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"土屋","familyNameLang":"ja"},{"familyName":"ツチヤ","familyNameLang":"ja-Kana"},{"familyName":"Tsuchiya","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一郎","givenNameLang":"ja"},{"givenName":"コウイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Koichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1567","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60114/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60114/profile-ja.html"},{"nameIdentifier":"70301314","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70301314"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"玉置, 俊晃","creatorNameLang":"ja"},{"creatorName":"タマキ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamaki, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"玉置","familyNameLang":"ja"},{"familyName":"タマキ","familyNameLang":"ja-Kana"},{"familyName":"Tamaki","familyNameLang":"en"}],"givenNames":[{"givenName":"俊晃","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"168","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10948/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10948/profile-ja.html"},{"nameIdentifier":"80179879","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80179879"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-11-05"}],"displaytype":"detail","filename":"labinvest_97_5_555.pdf","filesize":[{"value":"2.56 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006763/files/labinvest_97_5_555.pdf"},"version_id":"459e3d6b-2048-4cc2-a7ca-938911ae57c3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-05"},"publish_date":"2019-11-05","publish_status":"0","recid":"2006763","relation_version_is_last":true,"title":["Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:38:06.500910+00:00"}