{"created":"2024-10-29T00:57:49.125887+00:00","id":2006767,"links":{},"metadata":{"_buckets":{"deposit":"2e65dbc1-4441-48bb-9ae6-22af7df1a030"},"_deposit":{"created_by":7,"id":"2006767","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006767"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006767","sets":["1713853213384:1713853295607"]},"author_link":["386","521","1567","168","514","482","228"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-08-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"719","bibliographicPageStart":"709","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"European Journal of Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents. Serum ferritin, a marker of body iron storage, is elevated in various cardiovascular diseases, including hypertension. However, the associated changes in iron absorption and the mechanism underlying increased iron content in a hypertensive state remain unclear.\nMethods: C57BL6/J mice were treated with ANG II to generate a model of hypertension. Mice were divided into 3 groups: (1) control, (2) ANG II-treated, and (3) ANG II-treated and ANG II receptor blocker (ARB)-administered (ANG II-ARB) groups.\nResults: Mice treated with ANG II showed increased serum ferritin levels compared to vehicle-treated control mice. In ANG II-treated mice, duodenal divalent metal transporter-1 (DMT1) and ferroportin (FPN) expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced. The mRNA expression of bone morphogenetic protein 6 (BMP6) and CCAAT/enhancer binding protein alpha (C/EBPα), which are regulators of hepcidin, was also down-regulated in the livers of ANG II-treated mice. In terms of tissue iron content, macrophage iron content and renal iron content were increased by ANG II treatment, and these increases were associated with reduced expression of transferrin receptor 1 and FPN and increased expression of ferritin. These changes induced by ANG II treatment were ameliorated by administration of an ARB.\nConclusions: ANG II altered the expression of duodenal iron transporters and reduced hepcidin levels, contributing to the alteration of body iron distribution.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin Heidelberg","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14366207","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14366215","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11323696","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11622700","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"The final publication is available at link.springer.com."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00394-014-0749-1"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00394-014-0749-1","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"280180"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タジマ, ソウイチロウ","creatorNameLang":"ja"},{"creatorName":"タジマ, ソウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tajima, Soichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219499/profile-ja.html"},{"nameIdentifier":"60432754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60432754"}]},{"creatorNames":[{"creatorName":"榎本, 英明","creatorNameLang":"ja"},{"creatorName":"エノモト, ヒデアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Enomoto, Hideaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イマオ, ミズキ","creatorNameLang":"ja"},{"creatorName":"イマオ, ミズキ","creatorNameLang":"ja-Kana"},{"creatorName":"Imao, Mizuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"堀ノ内, 裕也","creatorNameLang":"ja"},{"creatorName":"ホリノウチ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Horinouchi, Yuya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"(井澤)石澤, 有紀","creatorNameLang":"ja"},{"creatorName":"(イザワ)イシザワ, ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa-Ishizawa, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"(井澤)石澤","familyNameLang":"ja"},{"familyName":"(イザワ)イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Izawa-Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"有紀","givenNameLang":"ja"},{"givenName":"ユキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"521","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229223/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229223/profile-ja.html"},{"nameIdentifier":"40610192","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40610192"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"木平, 孝高","creatorNameLang":"ja"},{"creatorName":"キヒラ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kihira, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"木平","familyNameLang":"ja"},{"familyName":"キヒラ","familyNameLang":"ja-Kana"},{"familyName":"Kihira","familyNameLang":"en"}],"givenNames":[{"givenName":"孝高","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"386","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90377276","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90377276"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 理人","creatorNameLang":"ja"},{"creatorName":"ミヤモト, リヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Licht","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"理人","givenNameLang":"ja"},{"givenName":"リヒト","givenNameLang":"ja-Kana"},{"givenName":"Licht","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"514","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60456887","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60456887"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石澤, 啓介","creatorNameLang":"ja"},{"creatorName":"イシザワ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizawa, Keisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"石澤","familyNameLang":"ja"},{"familyName":"イシザワ","familyNameLang":"ja-Kana"},{"familyName":"Ishizawa","familyNameLang":"en"}],"givenNames":[{"givenName":"啓介","givenNameLang":"ja"},{"givenName":"ケイスケ","givenNameLang":"ja-Kana"},{"givenName":"Keisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"228","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"141809/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/141809/profile-ja.html"},{"nameIdentifier":"60398013","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60398013"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土屋, 浩一郎","creatorNameLang":"ja"},{"creatorName":"ツチヤ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"土屋","familyNameLang":"ja"},{"familyName":"ツチヤ","familyNameLang":"ja-Kana"},{"familyName":"Tsuchiya","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一郎","givenNameLang":"ja"},{"givenName":"コウイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Koichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1567","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60114/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60114/profile-ja.html"},{"nameIdentifier":"70301314","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70301314"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"玉置, 俊晃","creatorNameLang":"ja"},{"creatorName":"タマキ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamaki, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"玉置","familyNameLang":"ja"},{"familyName":"タマキ","familyNameLang":"ja-Kana"},{"familyName":"Tamaki","familyNameLang":"en"}],"givenNames":[{"givenName":"俊晃","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"168","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10948/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10948/profile-ja.html"},{"nameIdentifier":"80179879","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80179879"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-10-15"}],"displaytype":"detail","filename":"ejn_54_5_709.pdf","filesize":[{"value":"1.96 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006767/files/ejn_54_5_709.pdf"},"version_id":"0a0de7f6-4e85-4a4a-81bc-ee3517f91700"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Iron metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin II","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepcidin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ferritin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-15"},"publish_date":"2019-10-15","publish_status":"0","recid":"2006767","relation_version_is_last":true,"title":["Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:47:29.016826+00:00"}