{"created":"2024-10-29T01:00:18.171184+00:00","id":2006799,"links":{},"metadata":{"_buckets":{"deposit":"73497ea2-95e4-4a51-964a-970f09185b15"},"_deposit":{"created_by":7,"id":"2006799","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006799"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006799","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1627","192","435","1631","190"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"腎臓の発達過程である新生児においてアンジオテンシノーゲンの発現は増強している","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Angiotensinogen expression in neonates","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"543","bibliographicPageStart":"537","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Nephrology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nWe recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development.\nMethods\nWe prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis.\nResults\nFifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age.\nConclusions\nEnhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Singapore","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Society of Nephrology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© Japanese Society of Nephrology 2018","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13421751","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14377799","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11126935","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3334号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-09-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Miki Shonoの学位論文として提出され，学位審査・授与の対象となっている。\nThis is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s10157-018-1662-3\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1428号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10157-018-1662-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-018-1662-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"370174"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"庄野, 実希","creatorNameLang":"ja"},{"creatorName":"ショウノ, ミキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shono, 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development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neonates","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Enhanced angiotensinogen expression in neonates during kidney development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhanced angiotensinogen expression in neonates during kidney development","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-12-10"},"publish_date":"2019-12-10","publish_status":"0","recid":"2006799","relation_version_is_last":true,"title":["Enhanced angiotensinogen expression in neonates during kidney development"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T07:46:13.906999+00:00"}